Essay on Summary And Conclusion Of Anti C1q Antibodies

9426 Words Oct 30th, 2016 38 Pages
Summary & Conclusion
Anti-C1q Antibodies C1q is a cationic glycoprotein of 410?450 kDa, which binds to the Fc portions of immunoglobulins in immune complexes to initiate complement activation via the classical pathway (Bigler et al, 2009).

C1q is produced by macrophages, monocytes, dendritic cells, fibroblasts, and epithelial cells and acts like a binding molecule between debris from cellular apoptosis (apoptotic blebs) and macrophages. Therefore, anti-C1q antibody development seems to be related to a deficiency in apoptotic cell clearance, as suggested by the fact that such antibodies from SLE patients specifically bind to C1q on apoptotic cells (Bigler et al, 2009).

Anti-C1q antibodies are commonly detected by ELISA. From a pathogenic point of view anti-C1q antibodies probably amplify glomerular injury but only when C1q has already been brought to the site by other types of glomerular-reactive auto-antibodies (Holers, 2004). Furthermore, Hegazy et al. 2012 reported in their study a strong correlation between anti-C1q antibodies and cutaneous lupus and hypothesised a potential pathogenetic role in such context.

Anti-Proliferating Cell Nuclear Antigen
(PCNA) Antibodies

Anti-PCNA antibodies can be detected by using IIF on cultured cells in which they show a characteristic nuclear speckled pattern of varying intensity), PCNA expression increases…

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