Role Of The Sympathetic Nervous System On The Pathophysiology Of Pdap

718 Words Dec 22nd, 2015 3 Pages
Several theories have been developed over the pathophysiology of PDAP. As for every other aspect of this condition it is difficult to draw conclusions as an uniform diagnostic group has not yet been defined. Historically, what we now call PDAP, has been hypothesized to be a vascular condition because of his frequent association with migraine headache and because pain can be perceived as throbbing (45). This theory has been discarded because of a lack of scientific evidence (2). Graff-Radford et al., defined atypical odontalgia as ‚Äúsympathetically maintained trigeminal neuralgia‚ÄĚ after observing the effectiveness of sympathetic blocks for pain reduction in a subset of atypical odontalgia patients (21). The role of the sympathetic nervous system in the pathophysiology of PDAP has not been further investigated since 1999 (46) and it may be interesting to have a deeper understanding of its involvement in this condition. In the last twenty years two main hypothesis have been explored. The first theory sees PDAP as a psychological condition, while the second one, that has been more extensively studied and is supported by stronger evidence, consider PDAP as a neuropathic pain disorder.

PSYCHOGENIC THEORY The rationale that is behind psychogenic theories as possible explanation of PDAP pathophysiology, is that among patients suffering from this condition there is an elevated prevalence of psychologic and psychiatric co-morbidities (8) (35) (36) (43). Depression,…

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