Postoperative Surgical Site Infection Paper

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1.1. Background information
Postoperative surgical site infections (SSIs) are a major source of morbidity and mortality in the surgical patient. It is the 3rd commonly reported nosocomial infection accounting for 10 to 40% of all nosocomial infections[1, 2].
In 2010, an estimated 16 million operative procedures were performed in acute care hospitals in the United States. A prevalence study found that SSIs were the most common healthcare-associated infection, accounting for 31% of all HAIs among hospitalized patients [3]. The CDC healthcare-associated infection (HAI) prevalence survey found that there were an estimated 157,500 surgical site infections associated with inpatient surgeries in 2011[4]. In the United States, SSI contribute to patients spending more than 400 000 extra days in hospital at a cost of an additional US$ 10 billion per year [5].
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A study published in 2004 reviewed data from 84 studies and estimated the economic costs of SSIs in Europe to range between $ 1.47–19.1 billion. It predicted also that the average patient stay would increase by approximately 6.5 days and cost 3 times as much to treat an infected patient. The analysis suggested that the SSI-attributable economic burden at that time was likely to be underestimated[7].
Recent work by the World Health Organization (WHO) Clean Care is Safer Care program shows that surgical site infection (SSI) is the most surveyed and frequent type of HAI in Low and middle income country’s and affects up to one third of patients who have undergone a surgical procedure. In LMICs, the pooled incidence of SSI was 11.8 per 100 surgical procedures (range 1.2 to 23.6)[8]. SSI was the most frequent HAI reported hospital-wide in LMICs and the level of risk was significantly higher than in developed countries

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