Bone and joint infections are considered as serious public health matter. They are mainly caused by bacteria and lead to bone loss. They are significant cause of morbidity and the cost of health care each year. In the statistics of 2008, it was noted that out of all hospitalizations in France, 0.2% were BIJs-related, which is equivalent to 54.6 cases per 100.000 population. These infections commonly affected original joint (68%) more than device-associated joint (32%). In terms of economic, the cost of BIJ was €259 million, or about €7,000 per hospitalization. This increase in cost is due to prolonged and repeated hospital stay, complex and long-term treatment protocol, and surgical intervention needs, [1]. Bone and joint infections are difficult
