Notes On Cyclic Enzymes And Its Effect On The Regulation Of Airway Smooth Muscle
PDE4 is the predominant PDE expressed in neutrophils, T cells and macrophages and therefore its inhibition may also have inhibitory effects upon both inflammatory and immune cells .
Chronic inflammation plays a central role in chronic obstructive pulmonary disease (COPD), and is characterized by an increase in neutrophils, macrophages and CD8+ T lymphocytes in small and large airways as well as in lung parenchyma and pulmonary vasculature . Therefore, it is not surprising that over the past two decades or so, many researchers are interested in the cAMP-specific PDE4 family because they considered it a potential intracellular target that could be exploited to therapeutic advantage for COPD and a multitude of diseases associated COPD .
Many PDE4 inhibitors were tested in recent years, and numerous studies with…