Multiple Thresholds For Different Components Of The Brain Ischemic Stroke Perfusion Imaging

8556 Words Oct 28th, 2015 35 Pages
Multiple Thresholds for Different Components of the Brain in Ischemic Stroke Perfusion Imaging
Stroke
Stroke is a disease of national and global significance in prevalence, impact and cost [1-4].?Stroke is the third leading cause of death and leading cause adult disability in Australia [3]. Furthermore, the number of stroke sufferers is expected to increase in the future as the Australian population ages[5]. Stroke can be categorized into ischemic and hemorrhagic subtypes. Each has a different mechanism and a different long term outcome. Ischemic stroke comprises 87% of all strokes occurring in Australia, and is caused by an occluded cerebral blood vessel. This occlusion results in hypoperfusion to tissue ?upstream? of the affected vessel that results in cellular death and dysfunction. The cellular death and dysfunction causes neurological deficit resulting in disability of the patient. Compare to ischemic stroke, hemorrhage stroke is relative rare in western countries. Of all strokes, only 10% are intracerebral hemorrhage (ICH), and 3% are subarachnoid hemorrhage (SAH) [1]. Both ICH and SAH are hemorrhagic strokes caused by blood vessel ruptures; in other words, bleeding in the brain. Comment by AB: Another brief linking sentence about how ICH is rarer than ischemic stroke rather than going straight back into a stat.
Pathophysiology of Ischemic Stroke
Infarct core
The brain maintains a high rate of oxygen and glucose consumption under normal homeostatic conditions. To…

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