Triazole Derivatives Essay

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PHYSICAL PROPERTIES:
It has two isomeric forms 1, 2, 3-triazole and 1,2,4-triazol with common molecular formula C2H3N3,and both have 69.06 molecular weight. [2]] 1, 2, 4-triazole derivatives simply exist in solid forms. 3, 4, 5-substituted 1, 2, 4-triazole derivatives melts on thermolysis when heated at high temperature3160C for half an hour. 1, 2, 4-Triazole derivatives are easily soluble in polar solvents and slightly soluble in non-polar solvents. However the solubility in non-polar solvents can be enhanced by substitution on the nitrogen atom.[[3]]The triazole ring is a frequent moiety present in various drugs such as Azosemide (diuretic), Brotizolam (appetite stimulant), Cefetrzine (antibacterial), Epoxiconazole (agricultural fungicide),
…show more content…
In 5-substituted-4-amino-3-mercapto-1,2,4-triazoles, the tautomerism in thion-thiol, thion gives absorption band at 1258-1166 due to the presence of C=S bond in it and further thiol gives absorption band in the region of 2700-2550 cm-1 for S-H bond. Two peaks with lower intensities obtained at 3350 cm-1 and 3250cm- 1 due to N–H bond also favours equilibrium in between thion-thiol. Also the N–H band appears in the regions of 3200 to 3100 …show more content…
Further inthe figure (B) the number of atoms can be seen.
L.Y. Wang et al [9] have done an effective1, 3-dipolar cycloadditionto synthesize 1, 3, 5- trisubstituted 1, 2, 4-triazole derivatives by reaction of oximeswith hydrazonoyl hydrochlorides in the presence ofbase triethylamine to get the desired 1, 3, 5-trisubstituted 1, 2, 4-triazoles in good amount. This reaction was capable for the substrates like aliphatic cyclic aliphatic, aromatic and heterocyclic oxime.
Y. Jiang et al [10] prepared 1- mono substituted aryl 1, 2, 3-triazoles (15) in good yields using acetylene from its source calcium carbide. The 1, 3- dipolar cycloaddition reactions were carried out without the protection of N and catalyzed by copper and in a MeCN/H2O

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