In Experiment 12B we used an umpolung reagent in an umpolung synthesis to synthesize benzoin from benzaldehyde. Umpolung synthesis is a synthetic approach that allows us to switch the identity of a reacting species. For example, the normal chemical reactivity of a nucleophile can be switched to one of an electrophilic compound. Two common agents are cyanide and thiamine (Vitamin B). The mechanisms for both agents are the same.…
The neutralization of the reaction was verified using pH paper to test whether the pH was neutral or slightly basic. At this point, the two possible products in the round bottom flask could have been exo- and endo-norborneol. Extraction and washing was performed and the exo- and endo-norborneol products formed were extracted into dichloromethane due to their similar solubilities, where the two products are overwhelmingly non-polar despite the one hydroxyl group. The dichloromethane (DCM) was the bottom layer formed, while the aqueous layer, the layer that was washed away, was the top and this was due to the weight of the chlorine atom that made DCM more dense. Extraction was repeated several times due to the partition coefficient, as it theorizes how smaller extractions are better than bigger extractions because they yield more concentrated extractions in the end.…
1) What is the first and last name of the incumbent, and what is their official title? (e.g. Assistant Director John Smith) Constance Ewing, Analytical Chemist II 2) How did you identify the incumbent? Constance Ewing also has a hairstyling and cosmetic business which operates on the weekends.…
Background The Grignard reaction is a reaction that form alcohols. The Grignard reagent is essential…
Stereochemistry 5. Introduction In this experiment, stereochemistry was explored by the isomerization of dimethyl maleate and the analysis of carvones. The isomerization was accomplished with the use of bromine, which broke the double bond to allow bond rotation. Free bond rotation allowed molecules to shift into the trans state before the double bond was reformed to create dimethyl fumarate.…
Experiment 5: Separating Ferrocene and Acetylferrocene by Adsorption Column Chromatography AIM The primary goal of this experiment is to separate ferrocene and acetylferrocene using adsorption column chromatography. Additionally, a dry pack method with a micro scale column will be implemented, and the percent recovery for each compound will be computed. TABLE OF PHYSICAL PROPERTIES AND HAZARDS WITH STRUCTURES Ferrocene: - Physical Property: Solid Molecular Weight: 186.04 g/mole Boiling Point: 249 °C Melting Point: 173.5 °…
The product is then determined by spectral and physical properties. Introduction The Grignard reaction is one of the most important reactions in organic chemistry. The reaction involves the Grignard reagent, which is formed…
This experiment has successfully synthesize an alkene product name Trans-9-(2-phenylethenyl)anthracene using the Wittig method. This involved creating an Ylide by reacting a base with benzyltriphenylposphonium. The Ylide reacts with an aldehyde reagent to yield the desired alkene product. The information in this lab can be used during the manufacturing of drugs by the pharmaceutical industry.…
This month I read the book The Compound by S.A Bodeen. This book was well written and fast paced, I like the suspense and the voice. I, however, thought that some of the plot points were a little predictable and at some points even drawn out. Overall I would rate this book an 8/10. In this book Eli and his family are forced into an underground bunker after a nuclear bomb leaves them shell-shocked and heartbroken.…
Gibson 1 Reagan Gibson Tripp Sanders Chemistry 1 May 2016 Introduction A Chemy Called Al is quite an interesting read. It is written by Wendy Isbell. It tells the story of a girl named Julie. The book begins talking about Julie and her electrical issues.…
The way scientists synthesize this cyclic product is through a Diels-Alder reaction. This reaction is very important in the synthesis of many other antibiotics and cyclic drugs. (Gujral, 2013) A Diels-Alder reaction is reaction between a conjugated…
One important aspect of organic chemistry is the synthesis of new compounds. It is also important for chemists to understand how to perform certain techniques, such as extraction and distillation, to produce the new products, which are usually drugs and cures for illnesses. In this experiment, n-butyl bromide was produced. n-Butyl bromide is an alkyl halide, which are usually synthesized by an alcohol and an acid. In the case of n-butyl bromide, n-butyl alcohol was used along with sodium bromide and sulfuric acid.…
These two steps were already carried out and 4 amino-phenol was the amine used in the first part of this experiment. 4 amino phenol and acetic anhydride undergo a nucleophilic addition-elimination reaction. A reaction mechanism is a step-by-step process when reactant molecules change in their geometry in order to produce new products. This occurs due to omission or addition of reagents, where bonds are broken down to form new ones4. 4 amino-phenol contains two functional groups, an OH and a NH2 group attached to a benzene ring while acetic anhydride is a derivative of a carboxylic acid group.…
The learning assistants for Professor Bahde’s Organic Chemistry I class, Allyson Dang and I, wanted to give the students a problem to work on involving a reaction mechanism. The students in that class have been struggling in many areas of the subject, but the main issue they have is drawing out reaction mechanisms. Knowing how to draw out reaction mechanisms is one of the most, if not the most important part of organic chemistry. When theoretically reacting molecules, one must know not only which molecules react with which, but also which parts of the molecules react with others.…
Aeshah Alrubayyi CHM 643 Reactive intermediate has been important investigated in physical organic chemistry. It classes to carbocations, carbenes, carbanions and free radicals. Recently, observable intermediate classified as reactive, and an unobservable intermediate is kinetically when occurs at a branch point in a mechanism. A reactive intermediate is formed in the rate determining step of a reaction and then goes to give products in low barrier. Also, the hydrocarbon reaction of terminal alkenes gives mixtures of primary and secondary boranes that formed in an exothermic biomolecular step.…