Guilt by association (GBA)(Lee, I et al., 2011) is a popular method for identifying disease genes. Through path ways, functional annotation and other concepts disease genes are identified. Another important concept is the interaction of gene with other type of gens. Here human gene network is analyzed against yeast data and identification of chromosomal intervals are done and based on that disease genes are identified. The method proposes (Guo, X et al., 2011) integration of two heterogeneous networks and applies a global ranking strategy on that. The basic assumption is that the gens with similar properties would lie in closed regions in the protein-protein interaction network. The association score between a query disease and associated
