The PPI network based gene prioritization can be defined as follows. In a PPI network G(V, E), calculate a score for each node vϵV based on the probability of v to be associated with a given disease of interest D using prior information about the disease. This prior information is represented as seed set S which contains genes known to be associated with D or diseases similar to D. The candidate set C is the set of all genes that has to be prioritized, and are extracted from the chromosomal regions provided by linkage or genome wide association studies. Genes in the candidate set are sorted and then ranked in the increasing order of the calculated score. Higher ranked genes are supposed to be most likely to cause disease D.\\
But the PPI networks
But the PPI networks