Gene Expression And Function Of Transcription Selection And Expression Is Mrna And Or Reducing Tumor Suppressor Activity

2059 Words Oct 19th, 2016 9 Pages
vThere are multiple aetiologies to cancer development and maintenance, which essentially exert a selection pressure for enhancing oncogenic gene expression and/or reducing tumour suppressor activity. The transformation process leading up to malignancy is a result of a biased cellular homeostasis that favours increased and uncontrolled growth and proliferation. One of the least explored yet fundamentally important cellular processes that controls oncogenic transcript selection and expression is mRNA translation. Dysregulation of the translation process can alter the cellular landscape that can lead to cancer initiation, maintenance, progression, invasion and metastasis1,2. Cap-dependent translation is the primary mechanism of mRNA translation in eukaryotic cells. The most common member of the cap-dependent translation machinery that is often upregulated in cancer is eukaryotic translation initiation factor 4E 1 (eIF4E1), a 25-kDa protein that serves to initiate cap-dependent translation via mRNA cap binding, a highly regulated rate-limiting step in translation initiation. eIF4E1 functions to bridge mRNA to the ribosome via the eIF4F complex assembly1,3–7. The oncogenic potential of eIF4E1 has been characterized in many model systems and is emerging as an attractive therapeutic target for cancer, giving rise to eIF4E/eIF4E-cap inhibitors like ISIS183750 and ribavirin in clinical trials8. The sole upstream regulators of eIF4E1 phosphoactivation are mitogen-activated protein…

Related Documents