Factors Of Insulin Resistance Syndrome

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Introduction
What is Insulin Resistance Syndrome?
Insulin Resistance Syndrome is a proven facilitator of an alarming number of chronic illnesses in the United States. In order to understand the severity of insulin resistance syndrome, it is vital to recognize the important role that insulin plays in the human body (Reaven, 1995). Insulin is a hormone produced by the pancreas which is instrumental in the body’s use of digested food for energy. The body’s digestive tract breaks down carbohydrates consumed into glucose which enters the bloodstream. Insulin aids the cells in the body to absorb and use glucose for energy. Insulin resistance occurs when the body’s cells do not react appropriately to insulin which makes it difficult to absorb glucose
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Studies have proven that members of the population with insulin resistance commonly have an excess body weight, elevated total cholesterol concentrations, increased concentrations of LDL cholesterol and decreased concentrations of HDL cholesterol which have been proven to be contributing factors in developing ACD. Though research varies on exactly how insulin resistance causes ACD, there is a proven correlation between the two (Aminot-Gilchrist & Anderson, 2004).
Data derived from World Health Organization Multinational Study of Vascular Disease in Diabetes showed that cardiovascular disease is the leading cause of mortality (52% of deaths) in individuals with NIDDM (Morrish, Wang, Stevens, Fuller, Keen, & WHO Multinational Study Group, 2001). This sobering evidence suggests that the rising incidence rates of insulin resistance syndrome and NIDDM coincide with the impact that ACD has on life expectancy.
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Studies in 2015 have proven it to be the second leading cause of liver disease among adults awaiting liver transplantation in the United States, well on its way to being the number one cause of liver disease requiring transplantation due to the linear increases cases of insulin resistance syndrome and other major contributing factors such as rising levels of obesity and unhealthy lifestyle (Wong, Aguilar, Cheung, Perumpail, Harrison, Younossi, & Ahmed, 2015). As of date, the only proven treatment for NASH is typically centered around the management of its associated conditions. Proper control of blood glucose and lipid levels is always recommended along with weight reduction in order to allow the liver to function uninhibited by the build-up of fat. The treatment of insulin resistance with weight management and dietary changes has been shown to make a considerable difference in the progression of NASH as research has not yet proven any medications to be effective in its treatment thus far (Angulo & Lindor, 2002). The simple fact that no other treatments are currently available for the treatment of NASH calls for an increased focus on the harmful effects of insulin resistance

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