There are 2 types of gene therapy they are “Germline therapy and Somatic therapy”. Germline therapy is a treatment that involves the adjustment of the genes inside the germ cells (ova or sperm). As zygote evolves, they would divide which, will then passed on the adjusted gene into different cells. While the Somatic therapy is the insertion of therapeutic…
Contrary to what one would expect based on the title of her book, The Forever Fix: Gene Therapy and the Boy Who Saved It, Ricki Lewis pens a narrative science focused on the milestones in the history of gene therapy, not just one success story (Lewis, 2012). Corey Haas, the boy who regained his vision after being sentenced to a life of blindness, is only one of the medical miracles mentioned; the book also devotes itself to presenting the theory and procedures behind gene therapy. As a supplement to the curriculum of the AP Biology course, the major biological concept of gene therapy in The Forever Fix: Gene Therapy and the Boy Who Saved It relates specifically to the third big idea in the AP Biology curriculum framework’s four major points.…
Methylation explains how one identical twin gets cancer yet the other does not because it explains how the same set of genes can produce different results depending on which genes have or have not undergone methylation. This occurs because genetic instructions are not unchangeable as we thought, but instead the DNA can remain the same while some genes are switched on or off. 33. We think that epigenetics can allow a grandmother to influence her grandchild’s DNA because we know that environmental factors and factors from the mother come into play when the baby is developing inside the mother. But for females, they are born with a full set of eggs that she will have for life.…
The Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance, written by Nessa Carey, is a uniquely constructed introduction to the world of epigenetics. Regardless of its recent emergence in science, Carey articulately ties in both historical context and scientific evidence to outline and support the developing knowledge of epigenetics. She uses scientific studies, advances, and even possible future developments of the field to engage and inform the reader. Although unbelievably interesting, the book is considerably dense, which yields its own benefits and disadvantages.…
The study of heritable changes in gene expression without a change in DNA sequence is defined as epigenetics. Epigenetics covers a variety of areas in life science such as, biological sciences, effect of pollutants, etc.. The study of epigenetics is important because it allows researchers to trace the causes of certain diseases, follow the effects pollution has in humans and understand how eating habits can alter a person's appearance. Epigenetic modifications can affect the level of expression and timing of specific genes. This in turn causes those genes to be on when they should be off or vice versa, the alteration may contribute to the formation of disease or the progression of it .…
After stem cell shots in their Eyes, three patients in Florida lose vision (2017) 1. Why would the U.S Stem Cell company use fat stem cells instead of undifferentiated stem cells? This is kind of a trick question; Stem cell therapy is still a new field of treatment. With that being, said stem cell therapy is very limited as to what it can treat. 2.…
Scientists and healthcare practitioners usually use the terms, genetics and genomics, interchangeably, but there are notable distinctions between the two areas of study. Genetics scrutinizes the functioning and composition of the single gene whereas genomics addresses all genes and their interrelationships to identify their combined influence in the growth and development of the organism (Beery & Workman, 2013). In the field of genomics, nurses can be involved in policy making, and adequate continuous research determines their practice in this context. Nurses are at the forefront of patient care, and they participate fully in genetic and genomic-based practice activities. Therefore, they have a critical role advocating for, educating, counseling,…
HUMAN GENOME PROJECT Be it resolved that the Human Genome Project is for the well-being of the human race. According to the National Human Genome Research Institute, the Human Genome Project was one of the great feats of exploration in history. This is because the Human Genome Project is all about examining a human body’s genome, and DNA structure, and the vigorous thing about that is that it is not just about researching, it is also about doing something righteous with the information that has been discovered. The National Human Genome Research Institute has claimed that they have devoted their time and effort to use the information that has been generated by the Human Genome Project to be able to ensure the most rapid application of research results for the benefit of humanity.…
Genetic counselors come from backgrounds in genetics and in counseling. They provide key information and guidance for expecting parents. A genetic counselor would be able to identify potential birth defects and genetic disorders. There are several different kinds of genetic counselors with specific areas of expertise. Depending upon the reasons a family sought out a counselor, can dictate what kind of counselor they get to work with.…
Epigenetics are responsible for the “ghost” of the genome, enabling organisms identical by genotype to differ significantly in phenotype. It is referred to as a ghost because it was previously undetectable, and therefore mysterious. One important experiment to epigenetics involved a gene in mice that tell their body when to stop eating. In a mouse that is yellow and fat, the gene is turned off by the epigenome, whereas in a brown skinny mouse the gene is turned on. Interestingly, when the fat mouse was only allowed to eat extremely nutritional food, it bore only pups with the gene turned on.…
Question: Can Stem Cell Modification cause unrealized consequences? Claim: Stem Cell modification can cause unrealized consequences Evidence 1: “While the positive therapeutic outcome was celebrated as a breakthrough in gene therapy, a serious drawback subsequently became evident. By February 2005, three children out of seventeen who had been successfully treated for X-linked SCID developed leukemia because the vector inserted near an oncogene (a cancer-causing gene), inadvertently causing it to be inappropriately expressed in the genetically-engineered lymphocyte target cell.…
Andrew Jakymiw at Medical University of South Carolina in two independent projects. In the first project, we studied the RNA interference (RNAi) biology and how dysregulation of its molecular components contribute to oral cancer pathogenesis. We were the first group to provide biochemical evidence for the existence of the Dicer1e transcript and characterize its product, Dicer1e, as a variant of Dicer1 proteins overexpressed in Oral squamous cell carcinomas (OSCC) cell lines of epithelial phenotype and in OSCC tissues. In the second project, I examined the feasibility of new methods to delivery RNAi-based therapies for oral cancer. By using a custom-made chimeric peptide as vehicle, we effectively introduced siRNAs into oral cancer cells and successfully silenced the target gene.…
Simone Francis Reference number: 2167-6527 Epigenetics is the study of modifications to the genes of organisms. The way in which our genes behave can be altered by our epigenomes without changing our DNA sequence. They can be altered by different factors of our environment such as what we eat, drink, etc. The video on epigenetics was very informative. Prior to watching the video, I had no knowledge of what epigenetics was nor have I ever heard about it.…
GENE SILIENCING Gene silencing is something that most people do not know about. It is part of molecular biology which is things to with the natural body and life but to a minute size. Gene silencing was developed and still developing by the RNAi team at CSIRO in Australia which was led by a British-Australian virologist and geneticist named Peter Waterhouse. This team of a few also had significant contributions from Ming-Bo Wang who helped Peter Waterhouse develop this technique. This technique is an innovation of Gene Shears and was discovered during the 1990s.…
Similarly, Sharma et al. (2010) find that while the majority of cells in a single cell derived non-small cell lung cancer subline are drug-sensitive, a small subpopulation of cells are drug-tolerant. Following removal of drug, these drug-tolerant persister cells expand and reacquire drug-sensitivity. Persister cells display an altered chromatin landscape, suggesting that epigenetic therapies could block persister cells. Indeed, treatment of cell lines with HDAC inhibitors or knockdown of the histone demethylase KDM5A reduces the emergence of persister…