Ebola Research Paper

Ebola: The Next Pandemic Throughout a lifetime, everyone encounters an illness at one point or another. Most people know someone who has had a serious medical condition such as cancer, an autoimmune disease, or a debilitating illness. However, many of these conditions take months or years to develop. Death from a medical condition normally doesn’t happen with in a few days. The Ebola virus is an exception. Soon after this virus invades the human body, hemorrhagic manifestations begin. This virus causes a miserable death due to bleeding from the inside out. The pathophysiology of this virus is unique and has only recently been understood to a moderate extent. Signs and symptoms are seen quickly and the severities of them are debilitating the …show more content…
The pathophysiology of Ebola virus is a complicated and detailed process because there are many events occurring within the body at the same time. According to The Journal of Virology, Ebola Virus Pathogenesis: Implications for Vaccines and Therapies, this virus tends to attach to endothelium cells and there are two different receptors for the virus to bind to, to begin the process of invasion. Lectin DC-SIGN can accommodate the binding of Ebola glycoprotein’s (GPs) to other cells, as well as folate-related receptors. Observation of the GPs has revealed that they undergo cleavage by cellular proteases when the virus enters target cells (JID). The Ebola virus secretes a molecule called sGP that initiates dimeric proteins to interact with neutrophils. This molecule also over sees the binding of neutrophils through a molecule called CD16b. The Ebola virus has the ability to enter macrophages and initiate the release of cytokines that causes a horrendous fever and inflammation (Bente, Gren. Strong & Feldmann, 2009 ). When endothelial cells are invaded, the vascular integrity is damaged. The barrier of blood to