Neurologic and retinal diseases
There are many different types of degenerative neurological diseases. The brain is a complex system and this makes the use of stem cells difficult to differentiate to the right cell type. The myriad connection between nerve cells and the complex interdependency with macroglia, which is made up of astrocytes, oligodendrocytes, and glial progenitor cells create a problem with creating precise structural reconstitution with stem cells. Neurological diseases including Alzheimer’s and Lewy body entail a multitude of neuronal phenotypes. This diseases exhibit both contiguous and transsynaptics patterns of spreading, which causes them to be poor targets for neuronal replacement strategies as they cannot be targeted. …show more content…
Pax3 and Pax7 only undergo partial myogenic differentiation but they still participate in skeletal muscle regeneration. MyoD and Myf5 use normal and dystrophic human PSCs to produce myoblasts as they regulate muscle differentiation or myogenesis. Also through intramuscular transplantation of human skeletal myogenic progenitors derived from PSCs, it creates and engraftment that adds to the satellite cells present. Additionally the removel of PSCs derived from patients with muscular dystrophie that are differentiated into satellite cells and mesoagioblast like cells. These cells have been genetically corrected and once reintroduced into dystrophic mice, it repairs their dystrophic phenotype. …show more content…
Once put into practice this technique would need an unlimited supply of a specific cell type to treat all regenerative therapies. One of the most important developments needed in stem cells is the hindering of the stem cell rejection. This has been done in some cases as seen above with liver disease viral hepatitis, but because each cell is different we will need different immune suppressions. There is not clear treatment yet in the case of DMD as there is no specific cell type that completely ameliorates the disease. Many of the hurdles in stem cells include finding the best place for the transplant or infusion site and dealing with the disruption of the extracellular matrix in treatment. Even with these challenges stem cells are an expansion in the treatment of many diseases including; diabetes, acute hepatic failure, metabolic liver diseases, retinal diseases, PD, HD, and possibly heart
There are many different types of degenerative neurological diseases. The brain is a complex system and this makes the use of stem cells difficult to differentiate to the right cell type. The myriad connection between nerve cells and the complex interdependency with macroglia, which is made up of astrocytes, oligodendrocytes, and glial progenitor cells create a problem with creating precise structural reconstitution with stem cells. Neurological diseases including Alzheimer’s and Lewy body entail a multitude of neuronal phenotypes. This diseases exhibit both contiguous and transsynaptics patterns of spreading, which causes them to be poor targets for neuronal replacement strategies as they cannot be targeted. …show more content…
Pax3 and Pax7 only undergo partial myogenic differentiation but they still participate in skeletal muscle regeneration. MyoD and Myf5 use normal and dystrophic human PSCs to produce myoblasts as they regulate muscle differentiation or myogenesis. Also through intramuscular transplantation of human skeletal myogenic progenitors derived from PSCs, it creates and engraftment that adds to the satellite cells present. Additionally the removel of PSCs derived from patients with muscular dystrophie that are differentiated into satellite cells and mesoagioblast like cells. These cells have been genetically corrected and once reintroduced into dystrophic mice, it repairs their dystrophic phenotype. …show more content…
Once put into practice this technique would need an unlimited supply of a specific cell type to treat all regenerative therapies. One of the most important developments needed in stem cells is the hindering of the stem cell rejection. This has been done in some cases as seen above with liver disease viral hepatitis, but because each cell is different we will need different immune suppressions. There is not clear treatment yet in the case of DMD as there is no specific cell type that completely ameliorates the disease. Many of the hurdles in stem cells include finding the best place for the transplant or infusion site and dealing with the disruption of the extracellular matrix in treatment. Even with these challenges stem cells are an expansion in the treatment of many diseases including; diabetes, acute hepatic failure, metabolic liver diseases, retinal diseases, PD, HD, and possibly heart