Classifications Of Osteogenesis Imperfect Causes Symptoms And Potential Treatment Options

1376 Words Nov 11th, 2016 6 Pages
Osteogenesis imperfecta describes a group of genetic disorders that are colloquially known as “brittle bone disease” and is estimated to affect around 7 out 100,000 people around the world. As the name suggests osteogenesis imperfecta is characterized by imperfect formation of the bones that leads to frequent fractures or breaks from minor trauma (Rauch et al., 2004). Depending on the severity of symptoms the impact to an affected individual 's life can differ. This paper will supply the necessary information for patients or those with family and loved ones afflicted by osteogenesis imperfecta to manage and understand their condition. Focusing on the four main classifications of osteogenesis imperfecta; the causes, symptoms and potential treatment options of each will be explained.
Osteogenesis imperfecta is most frequently classified using a system developed by Sillence and colleagues, who confirmed there are at least “ four syndromes” known as osteogenesis imperfecta. Sillence places patients into four clinical categories (Type I, Type II, Type III and Type IV) based on expressed symptoms, the most principal of which is the level of bone fragility (Sillence et al., 1979). Severity of bone fragility runs a touch out of order but going from least fragile to most fragile is; Type I, Type IV, Type III and Type II. Sillence’s classification system also takes into account multiple extraskeletal including color of the sclera and stature of the…

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