Florida State College at Jacksonville
Dr. James Stittsworth
Roher, A. E., Cribbs, D. H., Kim, R. C., Maarouf, C. L., Whiteside, C. M., Kokjohn, T.
A., et al. (2013). Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. PLoS ONE, 8(3), e59735. doi:10.1371/journal.pone.0059735
The neurological changes related to Alzheimer's disease (AD) heavily support the amyloid cascade hypothesis. Bapineuzumab is a monoclonal antibody that targets the N-terminal region of amyloid-B (Aβ) peptides. Three test subjects were treated with bapineuzumab to evaluate their changes in neuropathology and biochemistry. The levels of Aβ …show more content…
These hallmarks do not represent all of the causes of cognitive impairment however, which leads to the hypothesis that other factors such as cardiovascular pathologies, may also contribute to the development of AD. In order to evaluate the structural integrity of the microvasculature and its innervation, immunohistochemistry and direct neuropathological staining were used in three groups. These groups all consisted of using nonagenarians as test subjects. The first group was made up of nonagenarian AD patients who had a large amount of amyloid plaques. The second group consisted of nonagenarians who did not have dementia but had a high amount of amyloid plaques. The third group consisted of nonagenarians who did not have dementia or amyloid plaques. Results showed loss of vascular innervation, which was consistent with the hypothesis that other factors may contribute to the development of AD.
Leung, R., Proitsi, P., Simmons, A., Lunnon, K., Guntert, A., Kronenberg, D., et al.
(2013). Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. PLoS ONE, 8(6), e64971.