Amsacrine Research Paper

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Cancer is a disease affecting the world and the rise in treatments with drugs is just one way of delaying the process of the disease as well as improving the quality of life for the patient. Henceforth Amsacrine is one to watch out for due to its specific mode of action. Reference.

Amsacrine has an acridine chromophore with an amine at the 9 position (fig 1.) used in the treatment of some types of lymphoma or acute adult leukaemia [5]. It can also be known as Amsidine or m-AMSA [1]. Lymphoma is a cancer of the lymphatic system and leukaemia, a cancer of the blood [2,3]. These diseases are treated with drugs such as Amsacrine to destroy cancer cells. This management is referred to as chemotherapy.

Molecular target and mechanism of action
Amsacrine can work in two ways; one of them by blocking the enzyme
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Acridine is highly water insoluble but progress of water soluble by-products permitted them to act as chief reactants for synthesis of dyes, antiviral, antitumor, antiprotozoal, antimalarial, antibacterial and multidrug resistance modulator mediators. The acridine moiety (a part or a functional group of a molecule) is accountable for intercalation (the reversible inclusion or insertion of a molecule (or ion) into compounds) amongst base pairs of double-stranded DNA through π-π interactions and thus causes modification in the cellular machinery. This interaction skill consults to the molecules a high affinity for DNA, which is commonly considered as the biological goal for acridine anticancer agents. Amsacrine (m-AMSA) is the best-known compound of 9-anilinoacridine series. It was one of the first DNA-intercalating agents to be measured as a topoisomerase II inhibitor. 9-Anilino acridine derivatives have been widely studied as probable antitumor agents, since they are capable of binding to DNA

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