A Brief Note On Depression And Targets The Three Main Ptsd Clusters Such As Avoidance, Re Experiencing, And Hyperarousal

1061 Words Jul 19th, 2015 null Page
Studies show that SSRIs treats depression and targets the three main PTSD clusters such as avoidance, re-experiencing, and hyperarousal. SSRIs are tolerable and have few side effects. Serotonin-norepinephrine reuptake inhibitors block the reuptake of the neurotransmitters. SNRIs such as duloxetine, venlafaxine, and desvenlafaxine act by preventing the reuptake of the neurotransmitters serotonin and norepinephrine (Greenberg, 2012). High concentrations of extracellular serotonin and norepinephrine can improve mood and decreased depressive symptomatology (Greenberg, 2012). The typical dosages for SSRIs for the treatment of PTSD are in the ranges of 20 to 60 mg a day.
Brady and colleagues conducted a randomized, double-blind study of sertraline in patients with chronic PTSD with a minimum duration of symptoms of 6 months (Brady, 2000). According to Alexander (2012), a total of 187 patients were randomly assigned to receive 12 weeks of treatment. Either choosing sertraline (initiated at 25 mg/day and titrated as needed to 200 mg/day) or matched the placebo. At the end of treatment, sertraline provided significantly greater improvement in three of the four primary outcome measures. (The CAPS-2 total severity score, the Clinical Global Impression–Severity [CGI–S] rating, and the CGI–I rating) compared with placebo (Alexander, 2012).
Tricyclic Antidepressants
Antidepressants control the balance of noradrenergic neurotransmission and serotonergic that are useful in treating PTSD.…

Related Documents