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15 Cards in this Set
- Front
- Back
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Arachadonic acid |
AA league Precursor to prostanoids and leukotrienes |
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Phospholipase A2 (PLA2) |
PLA2y ball Hydrolyzes AA from the cell membrane |
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Cyclooxygenase -1 (COX-1) |
Head coach Cox Constitutively expressed Batters box = Thromboxane A2(TXA2) is synthesized by COX-1 Twisting hat = vasoconstriction Pro-slugger = produces prostaglandins Pro-slugger protecting Catcher with gastrointestinal pads = Produces gastric cytoprotective prostaglandins Prosluggers leave afferent tunnel = COX1 and 2 make prostglandins to dilate afferent arteriole |
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Cyclooxygenase - 2 (COX-2) |
Assistant coach Light on fire = Induced by inflammation End othelial dugout = COX2 is expressed in vascular endothelial and smooth muscle cells Procycler pitching machne = prostacyclin (PGI2) is made by COX2 Cycler with dialated red barrel = PGI2 causes vasodilation Procycler dispersing plates = inhibits platelet aggregation Prosluggers leae afferent tunnel = COX1 and 2 make prostglandins to dilate afferent arteriole Proslugger turns on sprinkler = COX2 makes prostaglandins to increase vascular permeability Pro-slugger in pain and hat on fire = Prostaglandins increase pain sensitivity and fever |
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Prostaglandins |
Activate sprinkler = COX2 synt |
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Non-steroidal anti-inflammatory drugs (NSAIDS) |
Fire extinguisher Aiming at assistant coach, but is also getting head coach = reversibly inhibit COX1 and 2 |
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NSAID side effects |
Burns hole in gastrointestinal pads = can cause gastric inflammation, erosions, and ulceration Ketchup on gasto pads = inhibition of COX1 can cause GI bleeding Ketchup on clock = COX1 inhib prolongs bleeding time Bursting from high pressure = Increase blood pressure by decreasing sodium excretion in kidney Baseball kidney containers=Can Cause acute interstitial nephritis Constricted hose= cause afferent arteriole vasoconstriction, lower GFR Sloughing off cleat spikes = NSAIDs cause renal papillary necrosis Elevated "lift-ium" balloons= Larger lithium conc. due to less excretion depleted Mineral mine with K board = Hypoaldosteronism and hyperkalemia |
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Diclofenac and ketorolac |
go blAC sox sign |
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Indomethacin |
Indigo sox Bone shaped balloon = NSAIDS can cause aplastic anemia, but Indomethacin most often |
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Meloxicam and piroxicam |
sOX CAM Meloxicam has a preferance for COX2, so less side effects |
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Naproxen |
ApPROXimatly 110mph |
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Aspirin |
ASA umpire Ejecting coaches irreversibly Acetlyation whistle Low dose = COX1 High dose = COX2 Kawasaki ATV = Treats kawasaki ATV Brain cap and Ray shirt= Reye Syndrome encephalopathy and hepatic dysfunction mudpileS = metabolic acidosis Blowing "-OH" bubbles = causes respiratory alkalosis Tin cans = Tinnitus can result Charcoal lines = activated charcoal absorbs aspirin |
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Aspirin Contraindications |
Cracked kidney shaped glass = avoid in acute kidney injury Exiting pregnant lady = risk of premature closure of ductus arteriosis (indomethacin and ibuprofin can cause this) |
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Celecoxib |
Celebrating catcher = Selective for COX2 inhibition Clean gastro pads = reduced ulcer and bleeding risk by avoiding COX1 inhibition Thrombus ice cubes= increase risk of ischemic cardiovascular disease Rotten eggs = Is a sulfa drug |
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Acetominophen |
Icy-medicine spray Inhibits COX2, acts as antipyretic and analgesic, not antiinflammatory Sprayed goat with liver = toxic levels of acetominophen deplete glutathione in the liver which is needed to inactivate the toxic NAPQI Charcoal Lines = activated charcoal absorbs acetominophen in acute toxicity N-flower seeds attracts goat= n-acetylcysteine can prevent toxicity before dmg is done by restoring glutathione stores |
