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11 Cards in this Set
- Front
- Back
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Purine Metabolism |
Purine shaped plate Small kid passing XO note = hypoxanthine XO love letter = Xanthine oxidase (hypoxanthine --> xanthine) Larger kid passing XO note = Xanthine (xanthine --> uric acid) |
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Acute gout |
Tripping Fire extinguisher = NSAID first line drug (indomethacin) Moon face = Glucorticoids (oral prednisone) treat acute gout Choir sings |
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Colchicine |
Choir sing Treats acute gout Spindly palm fronds = prevents microtubule polymerization by binding to intracellular tubulin First respnders blocked by choir = blocks cytoskeleton of neutrophils, inhibiting neutrophil migration, phagocytosis, and degranulation Muddy floor = can cause diarrhea |
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Pseudogout |
"Lying" on tablet = Acute treatment is similar to acute gout Blue rhomboid incense holder= pseudogout is positively birefringent (blue) and forms rhomboid-shaped crystals (Calcium pyrophosphate crystals) |
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Allopurinol |
Pure nun Manages chronic gout Grabs both XO notes = inhibits xanthine oxidase Sweeping up glass = Prevents uric acid deposition in tumor lysis syndrome Manages Lesch-Nyhan syndrome Purine beads = inhibits breakdown of purine analogs (6merecaptopurine and azathioprine) increasing risk of toxicity Sloughed off red mask = can cause Steven-Johnson syndrome Dress with Eo-slingshot = Eosinophilia and Drug Reaction with Eosinophilia and Systemic Symptoms |
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Febuxostat |
Stopped XO note Inhibits xanthine oxidase in chronic gout |
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Tumor lysis syndrome |
Shattered cancer crab Uric acid crytals can form in tumor lysis syndrome after starting cytotoxic chemotherapy White T-cell crusaders: common in treatment of lymphoma and ALL |
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Lesch-Nyhan syndrome |
Needle in flesh biting at hand Associated with hyperuricemia Managed by allopurinol |
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Probenecid |
Probation officer Cid Uricosuric agent Manages chronic Gout Prevents punk from grabing yarn in Aisle = Decreases renal tubular reabsorption of uric acid Accumulating yarn balls = can increase risk of renal stone formation Cid's purple pencil = prevents excretion of penicillin and other drugs Rotten eggs thrown = Sulfa drug |
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Aspirin |
ASA Umpire Prevents son from grabbing yarn = at high doses aspriin prevent uric acid reabsorption Little ASA umpire catches yarn = low doese inhibits uric acid excretion |
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Pegloticase |
Holy water just IN CASE Converts uric acid into water soluble allantoin Treats chronic goat Watermelon with bite = can cause hemolysis in G6PD deficiency (bite cells) Choking kid = can cause anaphylaxis Ivy veins = must be given via IV |
