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13 Cards in this Set

  • Front
  • Back
1st generation H1 blockers
diphenhydramine, dimenhydrinate, chlorpheniramine
- reversible inhibitors of H1 histamine receptors
-can cross blood brain barrier
- used for allergy, motion sickness, sleep aid
-tox: sedation, antimuscarinic, anti-aplha adrenergic
2nd generation H1 blockers
loratadine, fexofenadine, desloratadine, cetirizine
- blocks H1 receptors but decreased entry into the CNS
-used for allergy
LESS SEDATION than first generation

cetirizine can be used in BPH b/c it is far less antimuscarinic than the others
asthma drug isoproteronol
- nonspecific beta agonist. relaxes bronchial smooth muscle
-adverse effect is tachycrdia (B1)
asthma drug albuterol
- B2 agonist. relaxes bronchial smooth muscle
-use during an ACUTE attack
asthma drug salmeterol
- B2 agonist. long acting agent for prophylaxis
-adverse effects are tremor and arrythmia
asthma- (methylxanthines)- theophylline
- causes bronchodilation by inhibiting phosphodiesterase thereby decreasing cAMP hydrolysis.
- narrow therapeutic index. cardiotoxicity, neurotoxicity
- metabolized by P450
- treat overdose with a beta blocker
asthma drug
muscarinic antagonists
- competitive block of muscarinic receptors, prevent bronchoconstriction
- used for COPD
- prevents release of mediators from mast cells
-used ONLY for prophylaxis of asthma
beclomethasone, prednisone
- inhibits phospholipase thereby inhibiting sythesis of virtually all cytokines. inactivate NF-kB, the transcription factor that induces production of TNF-alpha
-used for chronic asthma
- 5-lipoxygenase pathway inhibitor
- blocks conversion of arachadonic acid to leukotrienes
zafirlukast, montelukast
- block leuktriene receptors
-good for aspirin induced asthma
guaifenesin (Robitussin)
- expectorant- removes excess sputum
- does not suppress cough reflex
- mucolytic
- can loosen mucus plugs in CF patients
- also used as an antidote for amphetamine poisoning (replenishes glutathione)