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10 Cards in this Set
- Front
- Back
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What are the various sites of measurement of drug concentration in the body? |
Invasive:
Non-invasive:
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How is a plasma sample collected? |
The concentration in plasma comprises of bound and unbound drug. |
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How is a serum sample collected? |
Although the protein composition is slightly different from that of plasma, the drug concentration in serum and plasma are virtually identical. |
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How is a whole blood sample collected? |
The blood drug concentration represents an average over the total sample. |
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What are the various extravascular routes of administration? |
Via alimentary canal: buccal, oral, rectal, sublingual Others: inhalation, intranasal, IM, SC, transdermal |
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What does disposition consist of? |
Distribution Metabolism Excretion |
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Define distribution. |
Distribution is the process of reversible transfer of a drug to and from the site of measurement and peripheral tissues. |
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What are the factors governing drug distribution? |
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What is the enterohepatic cycle? |
The enterohepatic cycle is a process where drug is secreted into bile, stored in, and released from the gallbladder. The drug then transits into the small intestine, and is reabsorbed back into circulation. It is a component of distribution. It may also result in a double peak phenomenon. |
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Define elimination. |
Elimination is the irreversible loss of drug from the site of measurement. Elimination consists of metabolism and excretion. This may be due to:
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