Pharmacology Block D Lecture 1(B)

Front 1

What are some ACE inhibitors

Back 1

Captopril, Enalapril, Lisinopril, Fosinopril,Ramipril

Front 2

What do ace inhibitors do

Back 2

Inhibit formation if angiotensin II by preventing conversion of angiotensin Iwhat

Front 3

What are the consequences of ACE inhibition

Back 3

Fall in circulating angiotensin II

reduced aldosterone secretion

Front 4

Whats another consequence of using an ACE inhibitor

Back 4

Renin increase as more angiotensin I production to angiotensin I-7 which has vasodilatory effeftd on MAS refeptor having a vasodilatory effect

Bradykinin isnt being broken down by afe so increased cough

Front 5

How are ACE inhibitors used in hypertension

Back 5

Decrease bp by reducing pvr(peripheral vascular resistance)

Inhibiton of bradykinin breakdown may play a role due to its vasodilatory properties

Increased formation of angiotensin I-7 which apposes actions of all

Front 6

What else does local inhibion of ace do for hypertension

Back 6

May directly prevent development of hypertrophy due to AngII Effects on cell function/growth

Inc formation of angiotensin I-7 has hypotensive actions

Front 7

What are some adverse effects of ACE inhibitors

Back 7

Hypotension

Renal failure in certain patients

Cough

Front 8

What are some other adverse effects of ace inhibitors

Back 8

Angio-oedema

Adverse effects on feotus

Front 9

What is the adverse effect angio odema

Back 9

Swelling of dermis/sub cutaneous tissue

Thought to be mediated by brady kinin and substance p (potent vasodilators causing vascular permeability and fluid leakage

Front 10

Can effects can ace inhibitors have for adverse effects on fetus

Back 10

Renal failure, rejal dysplasia, hypotension, pulmonary hypoplasia, oligohydramnios

Front 11

Angiotensin receptor blocking drugs

Back 11

Losartan

Valsartan

Irbesartan

Candesartan

Front 12

What are the effects or at1 receptor antagonists

Back 12

Similar to ACE inhinitors but;

Do not decrease angiotensin II LEVELS

dont cause cough

Dint know if they are as effective and safe as ACE inhibitors

Front 13

What are renin inhibitors and whats the types

Back 13

More specific inhibitors of RAS than ACE inhibitors

First generation and second generatiok

Front 14

Whats the first generation of Renin inhibitors

Back 14

Poor bioavailability due to peptide structure

Front 15

Whats the second generation of renin inhibitors

Back 15

Are non-peptides. Since 2012 aliskiren is the only renin inhibitor on the market

Front 16

What are the effects of renin inhibitors

Back 16

Similar pharmacology to ACE and effective in lowering Bp

Reduce angiotensin I levels, shouldnt cause cough, possible risk of combination of aliskerin and ace inhibitors/ARBs in patients with kidney impairment- remains to be established if they are as arfficive and safe as ACE inhibitors

Front 17

ACE inhibitors and ARBs are used in what

Back 17

Heart failure- improve exercise tolerance and reduce mortality

Hypertension

M.I

Front 18

What fo caucasians get for hypertension

Back 18

ACE inhibitors OR ARBS if these are not tolerated then a beta blocker

Front 19

What do afro-caribbeans get for hypertension

Back 19

Use Ca channel blockers as they dont respond well to ACE inhibitors they have diff renin levels

Front 20

What do patients get for heart failure

Back 20

ACE inhibitor and beta blocker plus diuretic