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9 Cards in this Set
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Define: indirect acting sympathomimetic drugs |
Drugs that stimulate / replicate the sympathetic nervous system without acting directly on adrenergic/ dopamine receptors (e.g. causing the release of endogenous catecholamines, or inhibits degredation) |
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MOA of amphetamine & methamphetamine?
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They are indirect sympathomimetic drugs. Work on peripheral by release of catecholamines, but work on CNS though release of biogenic amines (noradrenaline, dopamine, serotonin)
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MOA of tyramine?
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Indirect sympathomimetic drug. They are byproducts of tyrosine metabolism (often found in fermented food) that release stored catecholamines (norepinephrine)
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MOA of ephedrine?
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Indirect sympathomimetic drug foundin various plants. A direct mixed agonist (a and b) and enhances release of norepinephrine (mild stimulant)
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MOA of mono amine oxidase inhibitors? (MAO inhibitors)
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They are indirect sympathomimetic drugs. MAO-A functions in liver. MAO-B causes inhibition (the bad one) Can be used for treatment of parkinsons or depression.
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MOA of reserpine?
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Indirect sympathomimetic drug. Inactivation of storage vesicles and nerve terminals, causing inability to store catecholamines, leading to depletion.
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Therapeutic use of reserpine?
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1. Initially a antihypertensive, but must be used with diuretic (causes sodium retension) 2. Used in research to differentiate between direct and indirect acting sympathomimetic drugs.
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Side effects of reserpine?
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Since it causes catecholamines to deplete, it is very sedating and can cause serious depression.
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MOA of Guanethidine and Bretylium? |
They are indirect acting sympathomimetic drugs. They prevent the release of noradrenaline and are used as antihypertensives.
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