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9 Cards in this Set

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Define: indirect acting sympathomimetic drugs

Drugs that stimulate / replicate the sympathetic nervous system without acting directly on adrenergic/ dopamine receptors (e.g. causing the release of endogenous catecholamines, or inhibits degredation)

MOA of amphetamine & methamphetamine?
They are indirect sympathomimetic drugs. Work on peripheral by release of catecholamines, but work on CNS though release of biogenic amines (noradrenaline, dopamine, serotonin)
MOA of tyramine?
Indirect sympathomimetic drug. They are byproducts of tyrosine metabolism (often found in fermented food) that release stored catecholamines (norepinephrine)
MOA of ephedrine?
Indirect sympathomimetic drug foundin various plants. A direct mixed agonist (a and b) and enhances release of norepinephrine (mild stimulant)
MOA of mono amine oxidase inhibitors? (MAO inhibitors)
They are indirect sympathomimetic drugs. MAO-A functions in liver. MAO-B causes inhibition (the bad one) Can be used for treatment of parkinsons or depression.
MOA of reserpine?
Indirect sympathomimetic drug. Inactivation of storage vesicles and nerve terminals, causing inability to store catecholamines, leading to depletion.
Therapeutic use of reserpine?
1. Initially a antihypertensive, but must be used with diuretic (causes sodium retension) 2. Used in research to differentiate between direct and indirect acting sympathomimetic drugs.
Side effects of reserpine?
Since it causes catecholamines to deplete, it is very sedating and can cause serious depression.

MOA of Guanethidine and Bretylium?

They are indirect acting sympathomimetic drugs. They prevent the release of noradrenaline and are used as antihypertensives.