Clinical Formulations Of Desoxyn (Methamphetamine)

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Desoxyn (Methamphitamine )
Classification: CNS Stimulant/Anorexiant/
Sympathomimetic
MW: 149.237 g/mol pKa: 9.87 (at 25 °C)
Chemical Formula: C10H15N
IUPAC Name:
(2S)-N-methyl-1-phenylpropan-2-amine

Description
Methamphetamine comes under category of amphetamine type stimulants. Methamphetamine is an Amphetamine Anorectic and Central Nervous System Stimulant. Other than clinical usage as an oral form or Intravenous form, methamphetamine has been highly abused as street drugs by smoking, inhaling and sniffing to attain ecstasy.
Clinical formulations of Methamphetamine in Oral (5mg – 30mg) or Intravenous forms are used for the improvement in cognitive domain, distractibility, attention deficit hyperactivity disorder (ADHD), cardiac stimulation, treatment of narcolepsy by arousal for children 6 years or older. For adults, Desoxyn is also being used as exogenous short-term obesity adjunct by
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Down stream effects include aggressive in children, insomnia, psychosis, hallucination and mood swings due to increased Central nervous System stimulation.

Figure 1: Methamphetamine acts by both facilitating the release of catechecolamine, particularly serotonin, dopamine, non-adrenaline from nerve terminals in the brain and by inhibiting their uptake. This leads to an increase in synaptic concentration of these neurotransmitters and by increasing the permeability of blood brain barrier that results in increased stimulation of postsynaptic receptors through its binding at active sigma receptors [1]

The increased production of reactive oxygen species (ROS), reactive nitrogen species (RNS), and damage-associated molecular pattern molecules (DAMPs), the dysregulation of glutamate transporters(specifically, EAAT1 and EAAT2) and glucose metabolism, and excessive Ca2+ ion influx in glial cells and dopamine neurons.

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