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47 Cards in this Set
- Front
- Back
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Why might a chemotherapy regimen only have a minimal effect on certain tumors?
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tumor cells in resting phase (low growth fraction)
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Chemotherapy is most effective against cells that are ______________.
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replicating
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Solid breast tumors tend to have a ____ growth fraction.
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low
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Extravacation may cause _______ with administration of doxorubicin (Adriamycin)
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severe blistering (vesication) and extensive cellulitis or "red death"
[remember, if you "rub" your skin wrong, it will blister OR RUBy-colored blisters) |
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With no blood return on an IV push of doxorubicin (Adriamycin), the next step would be to...
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gently and slowly flush with 20-30 mL of saline while monitoring for pain or swelling
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With 3-4 weeks prolonged diarrhea, look for _____ and _____
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decreased serum albumin,
reduced serum potassium |
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A common side effect of ciplatin (Platinol) is...
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delayed n/v (24-48H p admin)
[remember "platinum" = goldschlager = delayed n/v] |
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ondansetron (Zofran) is..
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antiemetic
[remember Zofran is similar to "suffering", stops pt from suffering from n/v] |
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Diphenoxylate (Lomotil), an opioid and atropine combo, is on of the most effective _____ drugs
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antidiarrheal
[remember something about "tilling the loam" r/t diarrhea] |
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Administering fluorouracil (5-FU) and applying radiation therapy to the abdomen can cause...
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significant and prolonged diarrhea
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Sibutramine (Meridia) is...
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an anorexiant
[remember "I'm staying at the Meridian Hotel on the beach, so I won't eat to help my figure"] |
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Bisacodyl (Dulcolax) is...
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a laxative
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Toxic effect of bleomycin (Blenoxane)...
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pulmonary toxicity
(dose-related and age-related) [BLEOmycin = BLEW = Blue(cyanosis) OR "one blows air" (r/t breathing)] |
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Toxic effect of doxorubicin (Adriamycin)...
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cardiotoxicity
[remember: "Adrian!"... Rocky's got a lot of heart] |
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Toxic effect of vincristine (Oncovin)...
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neurotoxicity
[remember VINdictive CRISTIans seem to have some neurological problems] |
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Toxic effect of cyclophosphamide (Cytoxan)...
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hemorrhagic cystitis
[the letters "cy" start both words] |
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The agents most likely to cuase chemotherapy related second malignancies are...
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alkylating agents
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The chemotherapeutic process is: (1 thru 4)
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1. teaching
2. informed consent 3. physical assessment 4. administration of drugs |
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All chemotherapy drugs cause...
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bone marrow suppression (esp. WBCs)
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Normal range of neutrophils... (in %)
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55-70%
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Normal ranges for adult female:
Hematocrit Hemoglobin |
37%-47%
12-16 grams/dL |
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Normal range for platelet count...
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150,000-400,000/mm3
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Normal range for RBCs for adult female...
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4.4-5.4 million/mm3
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To help decrease diarrhea, eat...
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a low residue, semi soft diet
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Normal range for ANC/AGC...
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2500-6500/mm3
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To decrease n/v, avoid...
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fatty or spicy foods
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A metallic taste is a common complaint of client's receiving...
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cyclophosphamide (Cytoxan)
[remember 'cylons' are made of metallic and you'd certainly get a metal taste in your mouth if you kissed one] |
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etoposide (VP-16) PO causes what GI side effect? (x6)
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stomatitis, n/v, dyspepsia, anorexia, diarrhea, constipation
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doxorubicin (Adriamycin) PO causes what GI side effects? (x5)
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stomatitis, n/v, anorexia, diarrhea, esophagitis
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prednisone (Deltasone) PO alters GI tract by...
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enhancing n/v and peptic ulcer dev't
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Normal range for WBCs...
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5,000-10,000
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Do not administer chemotherapy to a client who...
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recently received a live virus immunization
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To treat chemotherapy-induced anemia use...
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epoetin (Epogen)
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It is better to _____ chemotherapy-induced n/v than to treat it when it occurs
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pre-treat
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Antitumor hormones or hormone antagonists such as nolbadex or Megace are the most commonly associated with what adverse effect?
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infertility
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_____ is more commonly associated with alkylating agents such as cyclophosphamide and Leukeran.
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Ototoxicity
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Biologic response modifiers such as Intron A may cause encephalopathy, and clients may become... (x2)
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suicidal and clinically depressed
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Mechlorethamine HCL (Mustardgen) is a potent ____
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vesicant
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If Mechlorethamine HCL (Mustardgen) extravasates, sub q and ID injection with _____ and application of _____ may reduce local irritation.
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isotonic sodium thiosulfate, ice compresses
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define: nadir
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period of the lowest WBC count after chemo
[remember Ralph Nader = lowest voted candidate in 2000] |
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Although many chemotherapy agents can cause _____, the antimetabolites are commonly known for causing this side effect.
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stomatitis
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_____ is a common side effect of vinca alkaloids
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cardiotoxicity
["vin" French for wine is said to bet good for the heart, vinca, not so good...] |
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Clients often experience _______ after administration of immunostimulants (e.g. filgristam (Neupogen))
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flu-like symptoms
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Cyclophosphamide (Cytoxan) is _____, esp with high doses
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cardiotoxic
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cytarobine (Cytosar-U) has the primary side effect of...
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GI bleed
["bine" as in "binds" you up] |
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paclitaxel (Taxol) is often infused on an inpatient setting b/c of risk of significant... (x4)
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hypotension, tachycardia, bronchospasms, and chest pain
(i.e. serious cardiovascular impairment) |
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A client with thrombocytopenia is at high risk for...
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bleeding
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