Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
How do Osmotic Diuretics work?
|
They Increase the urine volume/water excretion as well as the excretion of most electrolytes.
|
|
|
What are 3 Osmotic Diuretic drugs?
|
Mannitol (IV)
Sorbitol Isosorbide (orally for glaucoma) |
|
|
What enzyme produces hydrogen ions that are secreted into the kidney making urine acidic?
|
Carbonic Anhydrase
|
|
|
What drug was first discovered to inhibit carbonic anhydrase and render urine basic?
|
Acetoazolamide (Glaucoma)
|
|
|
What is the mechanism of action of Thiazide Diuretics?
|
They inhibit the Na/Cl symporter in the Distal Tubule.
They compete for the Cl binding site and inhibit Na/Cl reabsorption. |
|
|
What is another name for thiazides?
|
Saluretics
|
|
|
Draw a the basic structure of a Thiazide.
|
Thiazide
|
|
|
What portion of the Thiazide is important for diuretic activity.
|
The C-6 electron withdrawing group (Cl or CF3).
|
|
|
Compounds with CF3 at position 6 as opposed to Cl have this characterstic.
|
They are more lipophilic and have a longer duration of action.
|
|
|
Structurally, what else is important for thiazide activity?
|
C-6, C-7, 3,4 dihydro (saturation of double bond), C-2,C-3 positions
|
|
|
What is a Loop Diuretic?
|
A type of diuretic thats onset is quick and duration is short. It also has a more pronounced effect than most diuretics.
|
|
|
What is the example of this type of drug?
|
Furosemide
|
|
|
Draw Furosemide.
|
Furosemide
|
