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11 Cards in this Set
- Front
- Back
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What are the largest lymph nodes of the body?
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mesenteric lymph nodes (MLN)
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Which cells in the gastric epithelium take up antigens from the gut lumen?
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M cells
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Which cells can extend across the epithelial layer of the intestine to capture antigen in the lumen?
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dendritic cells
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Most immune system cells in mucosal tissue are what type of cells?
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activated effector cells
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How do cells in peyer's patches get back to mucosal tissues?
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They are imprinted with gut-homing properties (eg. alpha4:beta7 on effector T cell binds to MAdCAM-1 to enter the lamina propria then alphaE:beta7 binds to E-cadherin and CCR9 binds to CCL25 on the intestinal epithelium)
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What are IEL's?
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Intraepithelial Lymphocytes: CD8 + T cells, express CCR9 alphaE:beta7 in lieu of alpha4:beta7 and thereby bind to the intestinal epithelium instead of staying in the lamina propria
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What are the functions of IEL's?
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Recognition of peptide presented in the context of MHC class I results in release of perforin and granzymes. Fas-FasL interactions can induce apoptosis (these are the same ways in which CD8 CTLs kill cells)
NKG2D binds non-classical MHC class I molecules MIC-A and MIC-B that are expressed by enterocytes in response to stress, injury, infection or a toxic peptide (ex. alpha2-gliadin is a peptide fragment of gluten… Celiac disease) |
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By what mechanism do NK cells recognize infected epithelial cells?
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NKG2D binds to MIC on infected cell then releases lytic granules
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The polymeric immunoglobulin receptor is expressed on the basolateral surface of enterocytes and transports Ig____ across the mucosal surface
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A
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The receptor ________ transports IgG from the bloodstream into the extracellular space
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FcRn
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In humans, susceptibility to celiac disease is associated with expression of ________ or _________ molecules
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HLA-DQ2 or HLA-DQ8
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