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11 Cards in this Set

  • Front
  • Back
What are the largest lymph nodes of the body?
mesenteric lymph nodes (MLN)
Which cells in the gastric epithelium take up antigens from the gut lumen?
M cells
Which cells can extend across the epithelial layer of the intestine to capture antigen in the lumen?
dendritic cells
Most immune system cells in mucosal tissue are what type of cells?
activated effector cells
How do cells in peyer's patches get back to mucosal tissues?
They are imprinted with gut-homing properties (eg. alpha4:beta7 on effector T cell binds to MAdCAM-1 to enter the lamina propria then alphaE:beta7 binds to E-cadherin and CCR9 binds to CCL25 on the intestinal epithelium)
What are IEL's?
Intraepithelial Lymphocytes: CD8 + T cells, express CCR9 alphaE:beta7 in lieu of alpha4:beta7 and thereby bind to the intestinal epithelium instead of staying in the lamina propria
What are the functions of IEL's?
Recognition of peptide presented in the context of MHC class I results in release of perforin and granzymes. Fas-FasL interactions can induce apoptosis (these are the same ways in which CD8 CTLs kill cells)
NKG2D binds non-classical MHC class I molecules MIC-A and MIC-B that are expressed by enterocytes in response to stress, injury, infection or a toxic peptide (ex. alpha2-gliadin is a peptide fragment of gluten… Celiac disease)
By what mechanism do NK cells recognize infected epithelial cells?
NKG2D binds to MIC on infected cell then releases lytic granules
The polymeric immunoglobulin receptor is expressed on the basolateral surface of enterocytes and transports Ig____ across the mucosal surface
The receptor ________ transports IgG from the bloodstream into the extracellular space
In humans, susceptibility to celiac disease is associated with expression of ________ or _________ molecules