Coeliac disease is specific for its disruption in normal nutrition absorption within the mucosa of the small intestine due to the flattening of the villi within the lining of it due to its affects (1). Individuals primarily affected by coeliac disease are generally genetically predisposed to factors which illicit an autoimmune response on the mucosa of the small intestine (4). This causes the improper function of many digestive mechanisms responsible for protein uptake, more specifically in the processes of transglutaminase which is responsible for breaking down proteins rich with proline and glutamine such as that which is found within gluten (2).
HLA-DQ is a receptor located on the surface of antigen presenting cells and function in the …show more content…
These receptors have been characterized by their tendency to bind more readily to gliadin peptides (one of the proteins present in gluten) compared to their other forms which lead to the activation of T-cells and elicit an autoimmune response (1). The occurrence of this receptor is caused by the presences of a DQ2, DQ8 or both haplotypes located on chromosome 6 which encode for it. An individual who possesses the allele usually inherit it from either one parent or from both, the latter of which leaves them to be more susceptible to the autoimmune effects of it when encountered with gliadin …show more content…
This can only be contributed by tissue transglutaminase that has been crosslinked with gliadin as also functions as a type of carrier protein for the enzyme establishing a gliadin specific T-cell led mechanism (5). As a consequence of this, it elicits an anti-tissue transglutaminase response without the need of having T-cells specified for it (2). This constitutes for the majority of damage on the mucosal covering on the small
HLA-DQ is a receptor located on the surface of antigen presenting cells and function in the …show more content…
These receptors have been characterized by their tendency to bind more readily to gliadin peptides (one of the proteins present in gluten) compared to their other forms which lead to the activation of T-cells and elicit an autoimmune response (1). The occurrence of this receptor is caused by the presences of a DQ2, DQ8 or both haplotypes located on chromosome 6 which encode for it. An individual who possesses the allele usually inherit it from either one parent or from both, the latter of which leaves them to be more susceptible to the autoimmune effects of it when encountered with gliadin …show more content…
This can only be contributed by tissue transglutaminase that has been crosslinked with gliadin as also functions as a type of carrier protein for the enzyme establishing a gliadin specific T-cell led mechanism (5). As a consequence of this, it elicits an anti-tissue transglutaminase response without the need of having T-cells specified for it (2). This constitutes for the majority of damage on the mucosal covering on the small