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77 Cards in this Set
- Front
- Back
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What CD surface marker fits the following statement?
Displayed only by helper T cells |
CD4
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What CD surface marker fits the following statement?
Displayed only by cytotoxic T cells & suppressor T cells |
CD8
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What CD surface marker fits the following statement?
Found on all T cells (except NK cells) |
CD3
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What CD surface marker fits the following statement?
Used to ID B cells |
CD19, 20, 21
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What CD surface marker fits the following statement?
Found on all NK cells & binds the constant region of IgG |
CD16
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What CD surface marker fits the following statement?
Inhibits complement C9 binding |
CD55, 59
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What CD surface marker fits the following statement?
Endotoxin receptor found on macrophages |
CD14
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What cytokine(s) matches the following statement?
Promotes B cell growth & differentiation |
IL-4, IL-5
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What cytokine(s) matches the following statement?
Produced by Th1 cells |
IL-2, IFN gamma
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What cytokine(s) matches the following statement?
Produced by Th2 cells |
IL-4, IL-5, IL-10
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What cytokine(s) matches the following statement?
Involved in growth & activation of eosinophils |
IL-5
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What cytokine(s) matches the following statement?
Secreted by helper T cells & activates macrophages |
IFN gamma
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What cytokine(s) matches the following statement?
Inhibits macrophage activation |
IL-10
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What cytokine(s) matches the following statement?
Pyogens secreted by monocytes & macrophages |
IL-1, IL-6, TNF alpha
Acute phase cytokines |
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What cytokine(s) matches the following statement?
Inhibits production of Th1 cells |
IL-10
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What cytokine(s) matches the following statement?
Inhibits production of Th2 cells |
IFN gamma
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What cytokine(s) matches the following statement?
Mediate inflammation |
IL-1, IL-6, TNF alpha
Acute phase cytokines |
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What cytokine(s) matches the following statement?
Enhances synthesis of IgE & IgG |
IL-4
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What cytokine(s) matches the following statement?
Enhances synthesis of IgA |
IL-5
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What cytokine(s) matches the following statement?
Released by virally infected cells |
INF alpha, beta
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What cytokine(s) matches the following statement?
Supports growth & differentiation of bone marrow stem cells |
IL-3
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What cytokine(s) matches the following statement?
Supports T cell proliferation, differentiation & activation |
IL-2
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Which immunoglobulin isotype fits the following statement?
Associated with allergies b/c bound by mast cells & basophils and causes them to degranulate & release their histamine |
IgE
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Which immunoglobulin isotype fits the following statement?
Comprises 70-75% of the total immunoglobulin pool |
IgG
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Which immunoglobulin isotype fits the following statement?
Present in large quantities on the membrane of many B cells |
IgM, IgD
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Which immunoglobulin isotype fits the following statement?
Crosses the placenta & confers immunity to neonates in the 1st few months of life |
IgG
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Which immunoglobulin isotype fits the following statement?
Can occur as a dimer |
IgA
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Which immunoglobulin isotype fits the following statement?
Largely confined to the intravascular pool & is the predominant early Ab frequently seen in the immune response to infectious organisms w/complex Ag |
IgM
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Which immunoglobulin isotype fits the following statement?
Distributed evenly btwn the intravascular & extravascular pools |
IgG
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The predominant immunoglobulin in mucoserous secretions such as saliva, colostrum, milk, tracheobronchial secretions & GU secretions
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IgA
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Which immunoglobulin isotype fits the following statement?
Can be a pentamer |
IgM
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Which type of hypersensitivity is responsible for the following clinical problem?
Poststreptococcal glomerulonephritis |
III
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Which type of hypersensitivity is responsible for the following clinical problem?
Asthma |
I
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Which type of hypersensitivity is responsible for the following clinical problem?
Rheumatic fever |
II
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Which type of hypersensitivity is responsible for the following clinical problem?
Tuberculosis skin test |
IV
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Which type of hypersensitivity is responsible for the following clinical problem?
Allergies, anaphylaxis, hay fever |
I
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Which type of hypersensitivity is responsible for the following clinical problem?
Polyarteritis nodosa |
III
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Which type of hypersensitivity is responsible for the following clinical problem?
Serum sickness |
III
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Which type of hypersensitivity is responsible for the following clinical problem?
ABO blood type incompatibility |
II
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Which type of hypersensitivity is responsible for the following clinical problem?
Poison ivy |
IV
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Which type of hypersensitivity is responsible for the following clinical problem?
Eczema |
I
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Which type of hypersensitivity is responsible for the following clinical problem?
Contact dermatitis |
IV
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Which type of hypersensitivity is responsible for the following clinical problem?
Goodpasture's syndrome |
II
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5 causes of Elevated ESR
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1. Polymyalgia rheumatica
2. Temporal arteritis 3. Dz activity in RA & SLE 4. Infection, inflammation (osteomyelitis) 5. Malignancy |
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HYQ: Which complement is responsible for neutrophil chemotaxis?
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Complement C5a
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HYQ: A young child presents w/tetany from hypocalcemia & candidiasis resulting from immunosuppression. What cell type is deficient?
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T cell
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HYQ: A young child has recurrent lung infections & granulomatous lesions. What is the defect in neutrophils?
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Deficiency in NADPH oxidase
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HYQ: A mother brings in her 2yo child who has had multiple viral & fungal infections & is found to be hypocalcemic. Which of the 3 types of germ cells gives rise to the missing structure in this child?
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Endoderm
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HYQ: A child has an immune disorder in which there is a repeated Staph. abscesses. It is found that the neutrophils fail to respond to chemotactic stimuli. What is the most likely diagnosis?
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Job's syndrome
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What would you expect to see in a pt w/ Wiscott-Aldrich syndrome?
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{WAITER}
Wiscott Aldrich Immunodeficiency Thrombocytopenia & purpura Eczema Recurrent pyogenic infec Inc IgA, Dec IgM |
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What is the cause of granulomatous dz? What infections are these individuals susceptible to?
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1. Lack of NADPH oxidase (--> impotent neutrophils or phagocytes...lysosome doesn't work)
2. Catalase (+) [S. aureus, Klebsiella, Aspergillus, Candida]; Opportunistic infections |
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In what dz would you expect to see the following Ab?
Anti-mitochondrial |
Primary biliary cirrhosis
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In what dz would you expect to see the following Ab?
Anti-TSH receptor |
Grave's
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In what dz would you expect to see the following Ab?
Anti-centromere |
Scleroderma (CREST)
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In what dz would you expect to see the following Ab?
Anti-basement membrane |
Goodpasture's syndromw
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In what dz would you expect to see the following Ab?
Anti-neutrophil |
Wegener's granulomatosus/vasculitides (Micro poly, Churg Strauss, Pauci)
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What cytokine(s) matches the following statement?
Released by virally infected cells |
IFN alpha, beta
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What drugs are composed of Ab against TNF?
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- Enteracept
- Infliximab - Adalimumab |
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How does the mechanism of type II hypersensitivity differ from the mechanism of type III hypersensitivity?
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- Type I: Ab against self --> complement & macrophage damage
- Type II: Ab against foreign Ag (form complexes deposited in tissue) --> same damages |
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HYQ: A pt suffers from recurrent Neisseria infections. What complement proteins are deficient?
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C5, C6, C7, C8, C9 (membrane attack complex)
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HYQ: A 45 yo female complains of malar rash & arthritis. The presence of which Ab are specific for SLE?
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1. Anti-ds DNA
2. Anti-Smith |
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HYQ: After bone marrow transplantation, a patient suffers from dermatitis, enteritis & hepatitis. What dz process is occurring?
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Graft vs. Host dz
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Review quiz Q:
What are the phagocyte immunodeficiencies? |
- CGD
- Chidiak Higashi - Leukocyte deficiency syn - Job's syn/Hyper IgE |
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Review quiz Q: What are the x linked immunodeficiencies?
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{WBC}
- Wiskott Aldrich - Bruton's Agammaglobulinemia - Chronic granulomatous dz - Hyper IgM syn |
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To what immune cell does the following cell surface protein belong?
CD4 |
Th
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To what immune cell does the following cell surface protein belong?
CD14 |
Macrophages
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To what immune cell does the following cell surface protein belong?
CD16 |
- NK
- Macrophages |
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To what immune cell does the following cell surface protein belong?
CD19 |
B
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To what immune cell does the following cell surface protein belong?
CD3 |
All T cells except NK
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To what immune cell does the following cell surface protein belong?
CD8 |
Cytotoxic T cells
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Review quiz Q:
What immunodeficiency matches the following statement? Neutrophils fail to respond to chemotactic stimuli |
Job's syn (Hyper IgE) or Leukocyte adhesion deficiency
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Review quiz Q:
What immunodeficiency matches the following statement? Adenosine deaminase deficiency |
SCID
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Review quiz Q:
What immunodeficiency matches the following statement? Failure of endodermal development |
DiGeorge syn
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Review quiz Q:
What immunodeficiency matches the following statement? Defective tyrosine kinase gene |
Bruton's Agammaglobulinemia
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Review quiz Q:
What immunodeficiency matches the following statement? Associated with high levels of IgE and eosinophils |
Hyper IgE syn or Job's syn
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Review quiz Q:
What are the functions of interleukins 1-5? |
{Hot T Bone stEAk}
- IL 1: Acute phase cytokines/fever {Hot} - IL 2: T cell stim {T} - IL 3: Bone marrow stim {Bone} - IL 4: Enhance IgE, IgG production {E} - IL 5: IgA, eosinophils {A} |
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Review quiz Q:
Where would you expect to find B cells & T cells in the spleen? In the lymph nodes? |
B cells:
- Follicles of spleen & LN T cells: - PALS (Periarterial Lymphatic Sheath) of spleen - Pericortex of LN |
