6: Cns Medications: Psychotropic Conditions

Front 1

Define psychotropic agent

Back 1

A drug which alters the functioning of the mind (thinking, emotions, perceptions,...)

Front 2

Psychotropic agents are used to treat what disorders in the text book

Back 2

Depression
Anxiety
Schizophrenia
Bipolar

Front 3

Depression is caused by low levels of brain _______

Anxiety is caused by high levels of brain _______

They are both treated with "psycho________ agents"

Back 3

Norepinephrine

Norepinephrine

Psychotropic agents

Front 4

All of these drugs are examples of what?
Tricyclics
Monoamine Oxidase Inhibitors
Tetracyclines
Serotonin reuptake inhibitors
Serotonin and norepinephrine reuptake inhibitors

Back 4

Psychotropic Anti-depressants Agents

Front 5

All of these drugs are examples of what?

Sedative hypnotics
Beta Blockers
Buspirone

Back 5

Psychotropic Anti-anxiety agents

Front 6

The catecholamine theory of mood is....

Back 6

Moods are correlated with neurotransmitter Norepi

Front 7

Psychotropic agents work alter this chemical in the brain

Back 7

Norepi

Front 8

Tricyclics are used to treat ___________

Back 8

Depression

Front 9

The drugs of choice for treating severe depression are ___________.

Back 9

Tricyclics

Front 10

If a person was experiencing depression for reason like illness, death in the family, etc.... or, endogenous, neurotic, always have been depressed, what drug of choice would you use to treat him?

Back 10

Tricyclics

Front 11

Do the MOA of Tricyclics inhibit or increase the reuptake of Norepinephrine?

Back 11

Inhibits, because it's an anti-depressant.

Front 12

The side effects of Tricyclics are
1. __________ (occasionally)
2. Anti________ (give examples)
3. Cardiovascular (2 examples)
4. ________ dysfunction common with all antidepressants

Back 12

1.Sedation
2. Anticholinergic - dry mouth, blurred vision, constipation
3. Hypotension and arrhythmias
4. Sexual dysfunction

Front 13

Monoamine oxidase inhibitors (MAO) clinical uses are ________ and _________

Back 13

Depression
Hypertension

Front 14

Monoamine oxidase inhibitors (MAO) side effects are similar to tricyclics, but differ in what way

Back 14

MAO inhibitor is a CNS stimulant, and can cause a hypertensive crisis

*Both have: hypotension, G.I. 0 nausea, constipation. Anticholinergic - blurred vision, dry mouth, pee retention

Front 15

Monoamine oxidase inhibitors (MAO) contraindication include __________ & ___________ interactions. Also _______ failure

Back 15

Food and drug interactions.

Renal failure

Front 16

"Atypical" anti-depressant agents in the book include _______ and _______

Back 16

tetracyclic (not a tricyclic)
Serotonin reuptake inhibitors (SSRI)

Front 17

__________ are prescribed more frequently than any other class of therapeutic agent.

Short term or long term use?

Ineffective if use for _________ amount of time

Back 17

Anti-anxiety agents

Short term use

Ineffective if used for months.

Front 18

The 3 types of drugs used for treating anxiety are.

(They are all short term use drugs)

Back 18

Sedative-hypnotics

Beta Blockers (No sedation for addiction)

Buspirone (BuSpar) *may take 1-2 weeks to work.

Front 19

All ________ drugs block the effects on dopamine

Back 19

Antipsychotic drugs

Front 20

Neuroleptics is another name for ____________ agents

Back 20

Antipsychotic agents

Front 21

How do amphetamines effect schizophrenia, and what is the theory?

Back 21

Amphetamines make schizophrenia worse or cause psychoses in "normal" individuals.
Autopsy verifies patients have much higher levels of dopamine.

Front 22

How are dopamine levels effected with these drugs?
Amphetamines
Alcohol*
Levodopa
Antidepressant
Antipsychotics

Back 22

Increased (ex, AD-HD use)
Increased * Don't forget about GABA affects
increased (parkinsons)
Doesn't target dopamine, targets Norepi
Blocks dopamine effects.

Front 23

Therapeutic uses of Antipsychotic agents are (4)

Back 23

Schizophrenia
Manic phase of manic depressive until lithium works
Antiemetic (anti vomiting and nausea)
Hiccups

Front 24

Side effects of antipsychotic drugs/agents

Back 24

1 Sedation
2 Anticholinergic effects (dry mouth....)
3 Antiadrenergic effects (reflex tachycardia, postural hypotension
4 Extrapyramidal effects - locomotor effects (shaking)

Front 25

3 classes of antipsychotic agents are?

(All are equally effective)

Back 25

Phenothiazines (antiemetics) - more sedation, less extrapyramidal
Thioxanthenes - less sedation, more extrapyramidal
Butyrophenones - little sedatioin, higher extrapyramidal

Front 26

Lithium is used to treat

Back 26

Bipolar disorder

Front 27

What is the therapeutic use for Lithium

Back 27

Manic episodes - increased psychomotor activity, elation, aggression, grandiose ideas

Front 28

Lithium mechanism of action decreases ___________ neurotransmitter?
How does it affect the reuptake of that transmitter?

Back 28

decreases Norepi

decreases reuptake of Norepi

Front 29

Lithium competes with ______ ion. Essentially, where ever that ion is, it wants to take it's place

Back 29

Sodium (NA+)

Front 30

What is the connection between Lithium and the uncontrollable urge for water

Back 30

It competes with sodium causing an abnormal loss of sodium. Sodium is incredibly important in the transport of water.
*Increases urination and thirst.

Front 31

Which psychotropic drugs are sedating and not sedating?

Back 31

Sedating drugs - tricyclics (depression), sedative-hypnotics (anxiety), Antipsychotic agents (phenothiazines, thioxanthenes, butyrophenones)

Not Sedating - Lithium, MAO inhibitors (stimulant for depression)