Graves Disease is a condition within the immune system that appears as a result of the thyroid gland producing an overabundance of hormones. Deception occurs within the immune system of our body, eliciting a release of false, abnormal antibodies that are trying to imitate the normal chemical thyroid-stimulating hormone, TSH, by latching to the thyroid hormone receptor, TSHR, on the epithelial cells of the thyroid gland (Jin, Lawless, Sehgal, & Mchenry, 2012). This latching produces a plethora of thyroid hormones, T3 and T4, a process called hyperthyroidism (Prabhakar, 2013). Hypertrophy or goiter cells, are also stimulated due to the binding and activation of the TSHR (Menconi, Marcocci, & Marino, 2014). The mimicking results in an overproduction
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As found in the review article I selected, “Diagnosis and Classification of Graves ' Disease,” sweating, quivering, intense hammering of the heart, and noticeable weight loss, are seen as results of the high metabolism (Menconi et al., 2014). The body’s reaction to the oversupply of hormones compares with the body’s first symptoms of Graves Disease. The symptoms have an effect on many Systems of the body, such as the Skeletal, Cardiovascular, Metabolic, Dermatologic and Psychiatric. The Skeletal system experiences back pain, the Cardiovascular undergoes an intense drumming of the heart, the Metabolic system sees an increase in weight loss, sweating rises within the Dermatologic, and anxiety as well as restlessness affects the Psychiatric system (Yeung & Romesh, 2014). Graves’ disease is one of the most common endocrine disorders and according to Dr. Judy Jin, “is four to six times more common in women and it occurs most often in women between the ages of 20 and 50 years” (Jin et al., 2012, p. 1). Graves’ disease stems from the marriage of genetic and environmental factors. Thyroglobulin is an example of one of the thyroid specific genes that has been discovered and named, as well as the human leukocyte antigen- D related (HLA-DR), a susceptible immune regulatory gene found. Compared to the environmental effects of smoking, consumption of iodine, and contagions, the genetic probability of causation has proved to be low and has revealed that Graves’ Disease is not a product of heredity (Menconi et al.,
As found in the review article I selected, “Diagnosis and Classification of Graves ' Disease,” sweating, quivering, intense hammering of the heart, and noticeable weight loss, are seen as results of the high metabolism (Menconi et al., 2014). The body’s reaction to the oversupply of hormones compares with the body’s first symptoms of Graves Disease. The symptoms have an effect on many Systems of the body, such as the Skeletal, Cardiovascular, Metabolic, Dermatologic and Psychiatric. The Skeletal system experiences back pain, the Cardiovascular undergoes an intense drumming of the heart, the Metabolic system sees an increase in weight loss, sweating rises within the Dermatologic, and anxiety as well as restlessness affects the Psychiatric system (Yeung & Romesh, 2014). Graves’ disease is one of the most common endocrine disorders and according to Dr. Judy Jin, “is four to six times more common in women and it occurs most often in women between the ages of 20 and 50 years” (Jin et al., 2012, p. 1). Graves’ disease stems from the marriage of genetic and environmental factors. Thyroglobulin is an example of one of the thyroid specific genes that has been discovered and named, as well as the human leukocyte antigen- D related (HLA-DR), a susceptible immune regulatory gene found. Compared to the environmental effects of smoking, consumption of iodine, and contagions, the genetic probability of causation has proved to be low and has revealed that Graves’ Disease is not a product of heredity (Menconi et al.,