Uc Is A Chronic Idiopathic Inflammatory Disease Of The Gastrointestinal Tract ( Git )

973 Words May 7th, 2016 4 Pages
Introduction:
UC is a chronic idiopathic inflammatory disease of the gastrointestinal tract (GIT) that involves the large intestine and is a major disorder under the broad group of conditions termed inflammatory bowel disease, which also includes Crohn’s disease (CD). Dr. Samuel Wilks was the first to distinguish Ulcerative Colitis (UC) in 1859 when he described on “idiopathic colitis” and it has distinct features from the most common bacillary dysentery [1]. In that year, Sir Arthur Hurst wrote a complete description of Ulcerative Colitis which includes its sigmoidoscopy manifestations and distinction from bacillary dysentery [2].Ulcerative colitis is treating conventionally with 5-aminosalicylic acid (ASA), corticosteroids and oral immunosuppressant (e.g. azathioprine (AZA), 6-mercaptopurine (6MP)) with the goals of achieving clinical or mucosal remission, and/or eliminating long-term corticosteroid use [3]. Although, the conventional therapies are in many cases cannot be tolerated by the patients or ineffective.
This failure of conventional therapy of UC patients is due to frequent of colectomies was performed; the percentage of colectomy cumulative probability is 13.1% from primary diagnosis at 5 years, 18.9% at 10 years, and 25.4% at 20 years [4]. This deficit in widespread, effective treatment of UC patients, therefore, warrants the development and study of alternative treatments.
Tumor necrosis factor alpha blockers (Anti-TNF-α) is a potential alternative therapy for…

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