Treatment Immunosuppressives Or Corticosteroids Is Better For Treating Adolescents With Systemic Lupus Erythematosus

1655 Words Nov 21st, 2016 7 Pages

Of 11,996 articles, 15 articles were reviewed for this systematic review that were relevant to clinical research topic. The results from the articles were used to address the question which treatment immunosuppressives or corticosteroids is better in treating adolescents with systemic lupus erythematosus. Immunosuppressives reviewed in this paper are Hydroxychloroquine, Methotrexate, Cyclophosphamide, Rituximab, Azathioprine, Mycophenolate Mofetil, Anti-cytokines (including anti-TNF therapies such as Etanercept, Infliximab and Adalimumab). For corticosteroids there are Glucocorticoid, Prednisone and Methylprednisolone.


Hydroxychloroquine (HCQ) is an antimalarial medication that is used to treat childhood-onset systemic lupus erythematosus. According to a clinical study done by Arıcı, Batu, and Ozen (2015), HCQ is recommended for all SLE patients because of it’s nature to inhibit “toll-like receptor pathways” (Arıcı et al, 2015, p. 1). This study was done on individuals who have been diagnosed with juvenile systemic lupus erythematosus who are 18 years of age or younger. HCQ is a corticosteroid and has recently been used as a long term therapy among SLE patients. This long term use is seen as “the best conventional therapy we have offered to our patients” (Arıcı et al, 2015, p. 1). This specific medical intervention has the ability to modify the disease itself and “is associated with higher rates of renal response and fewer renal…

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