The Specific Types Of Monoaminergic Antidepressants Essay
A brief summary of the specific types of monoaminergic antidepressants will follow as it is important to note previous treatments of depression. Tricyclic antidepressants manipulate serotonin, and norepinephrine pathways through reuptake inhibition. These antidepressants are characterized by low levels of tolerability, and are rarely prescribed. Monoamine oxidase a inhibitors (MAOIs) increase synaptic monoamine availability. The issues of MAOIs arose from the avoidance of food with high levels of tryptophan/tyrosine because a possible potential for hypertensive crises, or, a sudden surge of serotonin, and impaired synaptic processing. SSRIs, or selective serotonin reuptake inhibitors cause excess amount of serotonin leads to a desensitization of the receptors, which could possibly explain the delay in therapeutic effects. Lastly, SNRIs (serotonin-norepinephrine reuptake inhibitor) are supposed to increase the effectiveness of the antidepressant, but evidence is shortcoming (Hasselmann, 2014). Based on an analysis of current antidepressant treatments, it becomes obvious that they lack in long-term effectiveness, and in safety, and tolerability levels.
Glutamate and Depression
Major depression, and treatment-resistant depression go beyond a monoaminergic insufficiency as recent studies have shown that antiglutamergic drugs, like ketamine, play a more significant role in treating depression. Glutamate, an amino acid that plays a…