The Endocannabnoid System

Decent Essays
The human endocannabnoid system is a homeostatic regulatory system with a substantive role in the dopamenergic. glutamenergic, and sertoerngic neural pathways. It is becoming the subject of modern pharmalogical research, due to its influence over the aforementioned pathways. The endocannabinoid system went long undiscovered due to its unique method of regulaton. The CB1 and CB2 receptors of the endocannabinoid system are located on the presynaptic cleft of the neuronal junction, as opposed to most neural systems, which house their receptors in the post synaptic cleft. This presynaptic positioning allows the endocannabinoid system to register the environment of the synapse. Signifying it as a promising catalyst for treatment and replacement

Related Documents

  • Improved Essays

    The synapses have receptors on them and the response of the drug depends on which receptor it binds to. Each receptor has its own response to a very specific drug. These responses can sometime benefit or harm the person depending on what drug binds to which receptor. 7. Present empirical evidence to support the position that the neurotransmitter is the signaling agent for…

    • 741 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Teratology, “Double Hit” Hypothesis, and the Concept Fetal Mal-Programming The third trimester of pregnancy (i.e., the prenatal period) and the first few years of life are crucial for brain development (Yang et al., 2011). During the early developmental stages in laboratory animals and humans, the ECSS is present in the CNS and plays a critical role in neuronal development and organization (Calvigioni et al., 2014). During the critical third trimester, the brain develops rapidly through the following sequential and interdependent processes: neurogenesis, axonal and dendritic growth, synaptogenesis, cell death, synaptic pruning, myelination, and gliogenesis (Yang et al., 2011). Intuitively, exogenous cannabinoid use during the critical stages…

    • 860 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    Background The movie set in Detroit. The main characters are two men: Ezekiel Whitmore (Spoon), Stretch. They are drugs addicts. They formed a band which is called Eight Mile Road with Spoon’s girlfriend - Cookie.…

    • 1150 Words
    • 5 Pages
    Improved Essays
  • Improved Essays

    In general, drugs work by imitating the brain’s neurotransmitters or over stimulating the brain’s “reward” circuit. Marijuana and heroin possess chemical structures that mimic naturally occurring neurotransmitters of our brain. These drugs are able to bind the receptors and activate the nerve cells. Because of differences of these drugs from the naturally occurring transmitters, abnormal messages may be sent through the brain; this may cause…

    • 458 Words
    • 2 Pages
    Improved Essays
  • Improved Essays

    Annotated Bibliography Carey, S. E., Nestor, L., Jones, J., Garavan, H., & Hester, R. (2015). Impaired learning from errors in cannabis users: Dorsal anterior cingulate cortex and hippocampus hypoactivity. Drug and Alcohol Dependence, 155, 175-182. doi:10.1016/j.drugalcdep.2015.07.671…

    • 2137 Words
    • 9 Pages
    Improved Essays
  • Improved Essays

    Modulation of pain occurs by different ways in order to inhibit the pain sensation. First, the endogenous opiates system, the naturally occurring opioids present throughout the central nervous system (CNS). Second, the descending system which is a pathway from the brain for natural pain modulation (inhibition) at the spinal cord, consist of descending neurons that synapse with the ascending neuron lead to releasing of the neurotransmitter such as endogenous opiates, serotonin, and gamma amino butyric acid (GABA) that suppress the pain signals and this explain the use of antidepressants and opioids in the treatment of chronic pain. Under normal condition, balance presents between the excitatory (glutametergic) system and the inhibitory (GABAergic)…

    • 133 Words
    • 1 Pages
    Improved Essays
  • Decent Essays

    The pituitary gland is a ductless endocrine gland that is split into two main parts: the anterior pituitary gland and the posterior pituitary gland. The pituitary gland is often referred to as the "master gland" because it produces hormones that control the rest of the endocrine system, such as the "thyroid gland, adrenal glands, ovaries, and testes" (endocrineweb.com). The pituitary gland itself is found behind the nose and at bass of the brain (patient.info). The posterior pituitary is the smaller, posterior lobe of the pituitary gland, and it is located inferior to the hypothalamus, the portion of the brain that maintains homeostasis, and it is also located posterior to the anterior pituitary gland. Furthermore, the posterior pituitary is…

    • 146 Words
    • 1 Pages
    Decent Essays
  • Decent Essays

    The results of this study show that lab animals who had been exposed to the drug known as Ecstasy, at levels comparable with human usage, experienced damage to brain serotonin neurons. After seven years had lapsed since original exposure to Ecstasy, the brains of the lab animals were tested to determine if the brain had repaired the damage previously done by the drug. Test results show that while several areas of the brain repaired the damaged serotonin neurons back to normal levels there were still multiple areas that showed little or no repair; an indication that the damage to brain serotonin neurons is permanent. Experimenters theorize that there may be a relationship between the proximity to the center of the damaged area as well as severity…

    • 263 Words
    • 2 Pages
    Decent Essays
  • Improved Essays

    Endocytosis Synthesis

    • 833 Words
    • 4 Pages

    Phagocytosis: The effects of time and Latrunculin on endocytosis. Introduction Phagocytosis is a process in which cells engulfed foreign materials. Eukaryotic cells can engulf different particles and solutes from their environment using a variety of mechanisms called endocytosis. Some cells can carry out large endocytic processes called phagocytosis and micropinocytosis. These processes can internalize particles (>0.5um) whereas internalization of fluids through micropinocytosis mechanisms or solute into vesicles for size less than (<0.5)…

    • 833 Words
    • 4 Pages
    Improved Essays
  • Decent Essays

    The brain allows you to think, breathe, move, speak, and feel. When drugs enter the brain, they interfere with its normal processing and can eventually lead to changes in how well it works. Over time, drug use can lead to addiction, brain disease and causes terrible consequences to their health and other parts of their lives. When someone puts drugs into their body, either by smoking, injecting, inhaling, or eating them, they mess with the brain’s communication system and mess with the way nerve cells normally send, receive, and process information. marijuana and heroin, have chemical structures that mimic that of a neurotransmitter that naturally occurs in our bodies.…

    • 236 Words
    • 1 Pages
    Decent Essays
  • Improved Essays

    The most affected system is the nervous system. It is the nervous system because when you receive a concussion your brain is pushed up against your skull. The brain transports messages to other parts of your body and since your brain is injured you are most likely to have trouble reacting to things and may not feel as much pain as you usually would. Two important parts of the endocrine system, the pituitary gland and the hypothalamus, are located in or near the brain. Traumatic brain injures (concussions) can injure them, causing hormone problems.…

    • 382 Words
    • 2 Pages
    Improved Essays
  • Decent Essays

    Endoplasmic Reticulum Stress induced Type II Diabetes and Heart Failure Background: The National Institute of Diabetes and Digestive Kidney Disease reports 1 in every 3 adults in America are considered to be obese. This is a record number compared to any other country. The mechanism, of which obesity contributes to diabetes and heart failure, is yet to be completely understood. A system of multifunctional organelle, the endoplasmic reticulum poses a significant contribution to diabetes inducing heart failure in humans. A site for protein folding, lipid synthesis, calcium ion homeostasis, and some metabolic functions, these networks of membranous sacs are currently the center topic of discussion.…

    • 451 Words
    • 2 Pages
    Decent Essays
  • Improved Essays

    Endocrine Mechanism

    • 983 Words
    • 4 Pages

    Endocrine regulation has begun very early in the development of a person. Every process in the body is kept balanced by the interaction of the nervous system and the endocrine system. The endocrine system is composed of endocrine glands that secrete hormones. Hormones are regulators of metabolism, growth, development, reproduction, and other activities. They also play roles in fluid and electrolyte balance, acid-base balance, and energy metabolism 1.…

    • 983 Words
    • 4 Pages
    Improved Essays
  • Great Essays

    Abstract Objectives: The anticonvulsant effect of cannabinoid compound illustrated in various models of seizure and epilepsy. On the other hand, there are controversial findings about the role of large conductance calcium-activated potassium (BK) channels in the pathogenesis of epilepsy. Also, there is no data regarding the effect of co-administration of cannabinoid type 1 (CB1) receptor agonists and BK channels antagonists in the acute models of seizure in mice. In this study, the effects of arachidonyl-2′-chloroethylamide (ACEA), as a CB1 receptor agonist, and BK channel antagonist, paxilline, either alone or in combination were investigated. Materials and Methods: The pentylenetetrazole (PTZ) or maximal electroshock (MES) acute models of…

    • 2125 Words
    • 9 Pages
    Great Essays
  • Superior Essays

    Therefore, regardless of the fact cannabis utilization does not have the evidence-based controlled trials to merit the beneficial use required for prescriptive authority, the trials to date, alongside the successful historical use of cannabis in treating ailments as compared to other viable solutions, may possibly oblige no further studies to demonstrate its therapeutic worth (Bostwick). 1. “Traditional Eastern medicine met Western medicine when W.B. O’Shaughnessy, an Irish physician working in Calcutta in the 1830’s wrote a paper extolling “Indian hemp” (Bostwick 173). “The list of indications for which he recommended cannabis-pain, vomiting, convulsions, and spasticity-strikingly resembles the…

    • 1590 Words
    • 7 Pages
    Superior Essays