The Cardiovascular Disease ( Cvd ) Risk That Affects Large And Medium Arteries

2905 Words Jun 20th, 2015 12 Pages
Cardiovascular disorders are currently the main mortality cause in the developed countries[1]. Atherosclerosis is the major contributor to the cardiovascular disease (CVD) risk that affects large and medium arteries. The disease is characterised by lipid deposition in the arterial wall, local inflammatory process and the formation of atherosclerotic plaques. Atherosclerotic plaques progress slowly, causing luminal narrowing of blood vessels, which by itself can lead to the ischemia of corresponding organs. However, most dangerous is the acute thrombus formation on the surface of a ruptured atherosclerotic plaque. Thrombosis can lead to rapid and life-threatening events, such as acute coronary syndrome and stroke[2]. Early stages of atherosclerosis development are mostly clinically silent, and the first manifestations of the disease are often fatal. At the same time, subclinical atherosclerosis is a prevalent condition in the modern society, especially among the ageing population. For instance, it has been reported recently that up to 5% of women and 12% of men over the age of 80 suffer from asymptomatic atherosclerotic carotid artery stenosis[3]. Other studies demonstrated that asymptomatic atherosclerosis is also common in young and middle-aged people, with up to 100% of apparently healthy individuals having atherosclerotic lesions at various stages of progression[4,5]. Along with the well-known benefits of the life style correction, the development of more specific…

Related Documents