Succinate-Coenzyme Q Reductase

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Succinate-coenzyme Q reductase (succinate dehydrogenase, SQR, Complex II) is an enzyme complex bound to the inner mitochondrial membrane of mammalian and many bacterial cells. It is the only enzyme that participates in both the citric acid cycle and the mammalian, mitochondrial, and bacterial electron transport chain.

Succinate dehydrogenase is also known as complex II in electron transport. The 4 subunit complex is bound in the mitochondrial membrane. Succinate dehydrogenase acts by oxidizing succinate into fumarate while passing electrons onto FAD which then is reduced to FADH2. FADH2 then passes its electrons onto the iron-sulfur centers found in the second subunit of the protein. After passing through the iron-sulfur centers, electrons

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