Purpura fulminans is a destructive thromboembolic condition that caused by meningococcal septicemia, leads to amputation. Septicemia from other bacteria (e.g., Haemophilus influenzae ), Kawasaki disease, toxic shock syndrome, or frostbite may also cause gangrene of the extremities. Protein S or C deficiency may cause Intravascular coagulation which causes tissue loss. One or all of the upper and lower limbs may be affected. Although purpura fulminant is a devastating, fulminant disease in the acute phase, with good intensive care, almost all patients who survive have no mental impairment and resume age-appropriate
