Physiology: A Case Study Of Poiseuille's Equation

2. Physiology
Q=(P1 - P2)/ R
Q= flow
The amount of a liquid moving past a point in a given amount of time.
P=Pressure (P1-P2)
The amount of force placed on an artery at any given point in time.
R= resistance
Is the force that must be overcome for flow to occur.
Describe the basic flow equation and resistance equation as they relate to vascular flow.
b. Define Poiseuille’s Equation, and describe the effect on blood flow of a change in each variable.

Poiseuille's equation states that the velocity of the steady flow of a fluid through a narrow tube varies directly as the pressure and the fourth power of the radius of the tube and inversely as the length of the tube and the coefficient of viscosity.
The Pressure Gradient (∆P) : The difference
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Re increases as velocity increases and viscosity increases. The higher the Reynold's number the likelihood of turbulence increases.
d. Define Reynolds’s equation, describing the factors that contribute to the likelihood of turbulent flow.

e. Describe the types of energy manifested in the circulatory system, and describe normal and abnormal causes of energy loss in arterial flow.

f. Describe and define the arterial energy wave and the effects of reflection and summing of these waves on blood pressure and pulsatility.
g. Describe and define local and general control of blood flow, vascular resistance, and blood pressure.
h. Describe and define types of arterial flow profiles, including where and when they occur.
Laminar flow:
Laminar flow is normal flow, the faster flow traveling through the vessel is in the center and the slower flow is closer to the vessel wall. This is due to wall drag.
Blunt flow ( plug
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pulsatile flow, rigid vs. distensible tubes, Newtonian fluid vs.

Antiplatelets are a group of medicines that stop blood cells (platelets) from sticking together and forming a blood clot. Whenever there is an injury in your body, platelets are sent to the site of the injury, where they form a blood clot. This is a very important mechanism in the body to stop the bleeding. Prevents formation of blood clots, for example in the carotid arteries.
Anticoagulantants are chemical substances that prevent or reduce the coagulation of blood, prolonging the clotting time.
Given a drug like Heparin acutely can limit the further formation of thrombus. When given chronically, for example Warfarin help prevent thromboembolism from the venous system (Leg veins). These drugs can also prevent clot formation in a dissected area.

Thrombolytic drugs dissolve blood clots by activating plasminogen, which forms a cleaved product called plasmin. Plasmin is a proteolytic enzyme that is capable of breaking cross-links between fibrin molecules, which provide the structural integrity of blood clots. Streptokinase, urokinase, alteplase, reteplase,

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