Pathophysiology of Hutchinson-Gilford Progeria Syndrome In order to conduct genetic research studies in hopes of finding a cure for the fatal disease progeria, one must understand how the disease affects the human body. Patients diagnosed with progeria demonstrate clinical signs of accelerated aging, including skin atrophy, osteoporosis, loss of subcutaneous fat and muscle, arthritis, poor growth, and alopecia. These manifestations are presented as a result of defects in the body’s processing and function of Lamin A. Lamin A is an intermediate filament protein that regulates a diverse number of cellular functions, including DNA repair.
Author’s Research Focus
Kan Cao, author of Progeria: Racing the clock to help young patients with old hearts,
Author’s Research Focus
Kan Cao, author of Progeria: Racing the clock to help young patients with old hearts,