A. Nitric oxide is an odorless gas that plays an important role in the regulation of pulmonary vasomotor tone. As inhalation occur, NO is diffused from the endothelium into the smooth muscles of the pulmonary vessel and stimulates soluble guanylate cyclase which converts GTP to cGMP. An increase in cGMP relaxes the smooth muscles and produces vasolidatory effects which increase the blood flow to well-ventilated areas with elevated vasomotor tone. Beneficial effects of inhaled NO include decrease in intrapulmonary shunting, improved oxygenation, initiation of bronchodilation, and possessing of anti-inflammatory properties.
B. iNO therapy can help newborns with persistent pulmonary hypertension, infants with hypoxic respiratory failure, infants
B. iNO therapy can help newborns with persistent pulmonary hypertension, infants with hypoxic respiratory failure, infants