The mast cells in the airway smooth muscle activated by allergen exposure, releases bronchoconstrictor mediators (histamine, cysteinyl-leukotrienes, prostaglandin D2) (Boyce 2003; Galli et al. 2005; Robinson 2004). Increased numbers of mast cells in airway smooth muscle leads to airway hyperresponsiveness (Brightling et al. 2002). Mast cells also can release a large number of cytokines to change the airway environment and promote inflammation even though exposure to allergens is limited. Macrophages are abundandly found in the airways and it can be activated by inhaled allergen through low-affinity IgE receptors to release many inflammatory mediators including cytokines that promoting the inflammatory response in asthma. (Peters-Golden 2004).
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It contains a inflammatory enzymes including eosinophil peroxidase , produce leukotrienes and releases a wide range of inflammatory and pro inflammatory cytokines, it leads to eosinophilic inflammation in asthmatic airway (Leckie et al. 2000). . Dentritic cell is a key antigen presenting cell, inhaled allergen interact with these cells in the airway epithelium and migrate to lymph node region. They interact with the regulatory cells in the lymph nodes such as T lymphocytes and B lymphocytes, stimulates the production of Th2 cytokine from native T cells (Kuipers and Lambrecht.2004). The structural cells such as airway smooth muscle cells and fibroblast are another important cells involved in asthma. The airway epithelium cell also critically involved in asthmatic airway. They produce asthmatic responses via the production of its own pro inflammatory cytokine, production of several growth factors which releases the inflammatory cytokines leads to airway inflammation and airway
It contains a inflammatory enzymes including eosinophil peroxidase , produce leukotrienes and releases a wide range of inflammatory and pro inflammatory cytokines, it leads to eosinophilic inflammation in asthmatic airway (Leckie et al. 2000). . Dentritic cell is a key antigen presenting cell, inhaled allergen interact with these cells in the airway epithelium and migrate to lymph node region. They interact with the regulatory cells in the lymph nodes such as T lymphocytes and B lymphocytes, stimulates the production of Th2 cytokine from native T cells (Kuipers and Lambrecht.2004). The structural cells such as airway smooth muscle cells and fibroblast are another important cells involved in asthma. The airway epithelium cell also critically involved in asthmatic airway. They produce asthmatic responses via the production of its own pro inflammatory cytokine, production of several growth factors which releases the inflammatory cytokines leads to airway inflammation and airway