Neurodegeneration Essay

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According to the National Institute of Neurological Disorders and Stroke, there are more than 600 neurologic disorders 1. Neurodegeneration is one of the main contributors to Alzheimer’s, Parkinson’s, and Multiple Sclerosis. Neurodegeneration is the debilitating condition along with those diseases, which results in the healthy, functioning nerve cells to deteriorate and slowly die off. Deterioration gradually leads to the loss of cognitive skills, motor skills, and eventually death of the nerve cell itself. Neurodegeneration can and will gradually get worse over time with the medicine today only slightly slowing down this horrible process. The Alzheimer’s Association approximates that there are 5.4 million people in the U.S. alone with Alzheimer’s, and the National Multiple Sclerosis Society estimates that over 400,000 people have MS in the U.S. let alone the 2 million other people around the world with the disease 4
According to the Alzheimer’s Association, by 2050, 115.4 million people are thought to be diagnosed with Alzheimer’s disease, and as of today, there is still no cure for this debilitating disease 4. The cause of neurodegeneration still has not been linked to specific genes or mutations, yet
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Inflammation is a common feature in neurodegenerative diseases in MS and AD. Resident macrophages in the central nervous system, microglial cells, act as a mediator for the nervous system in the effort of helping the body. In the case of MS, it does more damage than good. These microglial cells become chronically active and mediate the pathology inducing inflammatory responses which in turn results in the attack of healthy nerve cells. Multiple Sclerosis is an auto-immune disease, meaning that the body’s own white blood cells attack healthy cells thinking that this will bring the body back to homeostasis. This results in the ongoing degeneration of the nerve

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