Negative Effects Of Nephrotoxicity

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Nephrotoxicity is associate adverse effect of the anticancer drugs for solid and hematologic malignancies (Kintzel, 2001). Cisplatin, cisplatinum or cis-diamminedichloroplatinum (II) , a platinum-based drug, is one of the most frequently used anti-neoplastic agents. It has a potent anti-tumor action against wide range of malignancies, including testicular, ovarian, cervical, bladder and lung cancers as well as solid tumors resistant to other treatment regimens (Hanigan and Devarajan, 2003). The kidney is not only responsible for the excretion of cisplatin, but is also the primary site of its accumulation (Miller et al., 2010). Although several strategies have been suggested to prevent this adverse effect, no specific treatments are currently recommended, except for vigorous hydration with normal saline (Launay-Vacher et al., 2008). Therefore, new and effective therapeutic …show more content…
injection of 1 ml saline on day five; FEN group, received FEN 100 mg/kg /day orally (Camara-Lemarroy et al., 2009) for eight days; NAM group, received NAM 200 mg/kg /day orally (John et al., 2012) for eight days. Cis group, received single i.p. dose of Cis (7 mg/kg b.w.), the dose of Cis was selected according to previous work that demonstrated significant damage in renal parameters of rats (Atessahin et al., 2006); FEN+ Cis group, received FEN 100 mg/kg /day orally for eight days with single i.p. dose of Cis (7 mg/kg b.w.) on day five of the study period; NAM+ Cis group, received NAM 200 mg/kg /day orally for eight days with single i.p. dose of Cis (7 mg/kg b.w.) on day five; FEN+ NAM+ Cis group received FEN 100 mg/kg /day p.o. and NAM 200 mg/kg /day p.o. for eight days with single i.p. dose of Cis (7 mg/kg b.w.) on day five of the study

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