Microscale Synthesis of Acetylsalicylic Acid Essay

1214 Words Aug 29th, 2011 5 Pages
Synthesis of Aspirin

Ling Tecson Gamido, Mitchiko Mariel M. Mizukami
Abstract

Acetylsalicylic acid, or also known as aspirin is known to be a drug that relives people of pain and is commonly used even today. It is synthesized from salicylic acid and ethanoic anhydride, both of small quantities. Phosphoric acid was used as a catalyst in the synthesis to speed up the process. Esterification is involved and the final product is aspirin with the presence of acetic acid as the byproduct. In order to create the powder form of aspirin, the process of crystallization was conducted and was run through vacuum filtration. After running through the help of an electronic instrument, the result that was achieved in this experiment was met due to
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The value of % of transmittance is 1297.89. These values were done with the help of an electronic instrument.

Fig. 7

Figure 7. Infrared spectroscopy correlation library. This figure shows the presence of a match with ethyl salicylate with 35.48 which is labelled to be 1st in the results provided by an electronic instrument. The index is 1779.

Top 5 results

1. Ethyl Saliclate
2. Citral, 95%, mixture ofcis & trans
3. Salicylic acid inKBR
4. 3,5-Dimethyl-2-cyclohexen-1-one
5. 2,6-Dimethyl-g-pyrone

Discussion

The followings are the peaks that are present in Acetylsalicylic acid (Aspirin):

C=C (aromatic), 1600 – 1400 cm-1
C=O (ester), 1750 – 1730 cm-1
C=O (carboxylic acid), 1725 – 1700 cm-1
C-O (ester/carboxylic acid), 1300 – 1000 cm-1
O-H (carboxylic acids), 3300 – 2500 cm-1

The present of the pecks above determine the confirmation of aspirin in the synthesis result. As seen in the results, there were several peaks are seen at 1300-1100 which shows the presence of esters which is present in the final product of the synthesis of aspirin. The value of % of transmittance is 1297.89. These values were attained with the help of an electronic instrument. The possible source of error may include the excess of acetic anhydride and the lack of accuracy when it comes to the amount of salicylic acid. Some remained at the side of the

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