Microalbuminuria Research Paper

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INTR0DUCTION
‎ Vascular complications due to atherosclerosis are a major cause of ‎morbidity and mortality in type 2 diabetes mellitus(1). Microalbuminuria ‎now days is considered to be an atherosclerotic risk factor and predicts ‎future cardiovascular complications in diabetic patients, in elderly ‎patients, as well as in the general population(2). Microalbuminuria is ‎associated with cardiovascular mortality and morbidity in patients with ‎type 2 diabetes mellitus(3, 4). However, little is known about this ‎association. Specifically, it is not known whether microalbuminuria is ‎related to an early stage of atherosclerosis which manifested ‎radiologically by increased intima-media thickness (IMT) of carotid ‎arteries either common …show more content…
Arterial intima-media thickness ‎measurement obtained by B-mode ultrasound is currently recommended ‎by the American Heart Association as being relatively safe, noninvasive ‎and inexpensive method of assessing subclinical atherosclerosis and ‎being an independent predictor of atherosclerotic events(7).The IMT is ‎significantly higher in diabetic patients than that in nondiabetic ‎patients(8), and the increased IMT can predict future events of silent brain ‎infarction and coronary heart disease in the patients with type 2 diabetes ‎mellitus(9,10). Carotid artery plaque is another marker of systemic ‎subclinical atherosclerosis. But the previous reports showed the ‎inconsistent associations among IMT, plaque, risk factors, and clinical ‎disease(11,12). And which one is a more powerful predictor of vascular ‎outcomes, IMT or plaque, is still in controversy(13). In addition, the ‎reported results of the relationship between microalbuminuria and carotid ‎IMT is also different(14,15). Therefore, in this study, we explore the ‎relationship between microalbuminuria and Carotid Artery Intima-Media ‎Thickness in type 2 Diabetes Mellitus to decide the predictive value of ‎carotid artery intima-media thickness as an index of early

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