Fibrodysplasia Ossificans Progressiva Research Paper

Improved Essays
Encephalitis Lethargica (EL) and Fibrodysplasia Ossificans Progressiva

(FOP) are both disorders that affect a certain bodily System. Bodily Disorders

can upset homeostasis and cause problems with even the most normal

functions that the body performs. EL and FOP are two such disorders that

can wreak havoc on the body and severely inhibit a person's ability to

function regularly.

Encephalitis Lethargica and Fibrodysplasia Ossificans Progressiva are

disorders of the Nervous System and Skeletal System, respectively. The

earliest recorded cases of FOP present themselves in the seventeenth and

eighteenth centuries. The cases were recorded by the French physician, Guy

Patin, in 1692, and the British physician,
…show more content…
Regarding Encephalitis Lethargica, there have been

reports since the late sixteenth century regarding the epidemic outbreaks, in

various European countries, of a disease that at least appears similar to EL.

The name Encephalitis Lethargica was given by its discoverer, the

neurologist, Constantin Von Economo, in the year 1916 in an early stage of

the epidemic that occurred during and after World War I.

FOP has no cure nor an effective treatment, however, drugs used to

inhibit bone growth may help with the progression of the disorder and

steroids can help reduce inflammation that may trigger flare-ups. In

diagnosing FOP, the person with FOP will have a distinctive malformation of

their big toes. EL also has no known cure nor any form of obviously
…show more content…
FOP affects the Skeletal system in the way that tendons and

ligaments, key connective structures, are ossified, turned to bone, possibly

severely inhibiting movement. The inflammation involved in EL can damage,

or destroy, certain regions of the brain. Because of the damage caused, the

victim can become severly debilitated in a plethora of ways, some even

leaving the victim in a Parkinson's-like state. Determining the mortality rate

of EL is difficult given the infrequency of its appearance following the end of

its last outbreak that lasted from 1917 to 1928. Victims of FOP have a

severely shortened lifespan, only about 40 years, and their deaths are most

often directly linked to FOP. EL has fewer obviously harmful physical signs

than FOP but one can notice various changes in behaviour and motor

abilities in addition to its first phase which can be deadly due tooo the

possibility of respiratory failure. FOP can cause, sometimes painful,

swellings on the neck, shoulders, and back that eventually disappear, but

Related Documents

  • Decent Essays

    Subacute Sclerosing Panencephalitis, Pediatric Subacute sclerosing panencephalitis (SSPE) is a rare brain condition that develops months or years after a measles infection. It usually starts before age 20 and gets worse over time. SSPE causes brain swelling (encephalitis) and a loss of the protective covering that surrounds nerves (demyelination). It leads to a gradual loss of mental and physical abilities. CAUSES…

    • 317 Words
    • 2 Pages
    Decent Essays
  • Superior Essays

    Other illnesses, likewise, such as polio was an embarking widespread dilemma in the early 20th century. However, scientists and doctors were lead to a promising and effective…

    • 1103 Words
    • 5 Pages
    Superior Essays
  • Improved Essays

    For my essay I choose to write about rare genetic diseases from the nervous and skeletal systems. Though different systems, the nervous and skeletal system communicate well between each other. The skeletal system consist of all the bones in the body. The vertebrae and skull, both major parts of the skeletal system, house the 2 main structures of the nervous system: the spinal cord and brain. The vertebrae protects the spinal cord from injury while the skull protects the brain.…

    • 777 Words
    • 4 Pages
    Improved Essays
  • Superior Essays

    There are more than 200,000 US cases per year with an estimate ranging from 1.5 to more than 4: 1,000 live births or of defined age range. Symptoms can appear during infancy or preschool years. It affects “. . . body movement, muscle control, muscle coordination, muscle tone, reflex, posture, and balance. It can also impact fine motor skills, gross motor skills, and oral motor functioning.”…

    • 1887 Words
    • 8 Pages
    Superior Essays
  • Decent Essays

    Dbq Mental Illness

    • 150 Words
    • 1 Pages

    It was eventually recognized that this illness was caused by syphilis. This is the first documented link between an identifiable brain infection…

    • 150 Words
    • 1 Pages
    Decent Essays
  • Improved Essays

    Marfan Syndrome Near the end of the 19th century a french doctor Antoine Marfan was the first doctor to notice the effects of a common disorder (Atinder). Marfan syndrome is a genetically inherited disorder that affects the connective tissues that exist through the body. Specifically, Marfan syndrome alters the FBN1 gene and this affects the production of fibrillin (NHGRI). Fibrillin is a protein that is produced by the body to give strength to connective tissue.…

    • 608 Words
    • 3 Pages
    Improved Essays
  • Decent Essays

    Fibrodysplasia ossificans progressiva (FOP) or the stone man syndrome is a disorder in which the muscle tissue and connective tissue such as tendons and ligaments are gradually replaced by bone. The extra skeletal bone formation causes the person loss of mobility as the joint become affected. Overtime the person affected with FOP has difficulty difficulties breathing, speaking, and eating. Due to their eating problem they may experience malnutrition.…

    • 317 Words
    • 2 Pages
    Decent Essays
  • Improved Essays

    Krabbe disease Brief description of the disorder: Krabbe disease, a rare genetic degenerative disorder of the central and peripheral nervous systems. It is initiated from a lack of galactocerebrosidase, a vital enzyme for myelin metabolism. This disease is one of a group of genetic disorders called the leukodystrophies, which affects the growth of development of the myelin sheath, the fatty substance that insulates and protects the nerves in the brain and spinal cord. The myelin sheath continues to develop after birth, with the growth rate peaking before 18 months of age. The myelin sheath is completely developed when a person is about 20 years old.…

    • 446 Words
    • 2 Pages
    Improved Essays
  • Decent Essays

    The trials all began in the January 1692. The niece of Reverend Samuel Parris became sick. The doctor of the town, William Briggs, was called to help better the girls health. He diagnosed the ill girl with witchcraft, which sent the entire witchcraft into motion.…

    • 369 Words
    • 2 Pages
    Decent Essays
  • Improved Essays

    Dementia is an umbrella term. By this I mean that it covers many different conditions. Each condition affects the brain and can lead to dementia due to brain de deterioration and loss of function. Wernicke-Korsakoff syndrome- this is a brain disorder in which not getting enough B1 vitamin will affect your brain function. B1 vitamin is used in the brain to change sugar into energy.…

    • 356 Words
    • 2 Pages
    Improved Essays
  • Improved Essays

    The Black Death was one of the biggest diseases that had spread all throughout Medieval Europe. There was no cure for this disease so it got worse and worse. I will be telling you what all the Black Death also called the Black Plaque had done to this country and the types of medicine they had. This all happened during the 1350s all across Europe.…

    • 461 Words
    • 2 Pages
    Improved Essays
  • Decent Essays

    Morgellons disease Morgellons disease is a poorly understood condition which a growing number of physicians believe to be a chronic infectious disease. The disease can be both disabling and disfiguring. The side effects incorporate tingling, gnawing and creeping sensations, "fibers" or strands which rise up out of the skin, skin injuries which run from minor to distorting, joint agony, weakening weariness, changes in insight, memory misfortune, inclination unsettling influence and genuine neurological signs. In spite of the fact, that the Centers for Disease Control and Prevention (CDC) is as of now examining the disease. It is not yet completely perceived by the medicinal group.…

    • 355 Words
    • 2 Pages
    Decent Essays
  • Improved Essays

    Identify the disease process presented by the case study as well as the normal structure and function of the organ system and/or physiological process that has the alteration. Shawn, the main character of “The Uniformed Coach” scenario has sickle cell disease (SCD) and is suffering from a sickle cell crisis. Sickle cell disease is a form of hemolytic anemia that is inherited; being caused by an abnormal hemoglobin molecule. There are several forms of SCD but the most severe is simply called sickle cell anemia; the dysfunctional hemoglobin molecule, called hemoglobin S (Hb S), assumes an unusual shape when it is subject to deoxygenation or dehydration (McCance & Huether, 2014). In a normal person, all hemoglobin molecules are shaped like…

    • 1703 Words
    • 7 Pages
    Improved Essays
  • Great Essays

    In the year 1868, a disease that affects the central nervous system was identified. In the studies of Jean-Martin Charcot, he named the disease that would eventually become known as “Multiple Sclerosis”. Multiple Sclerosis, or MS, is an autoimmune disease that makes your body attack the covering of the axons of the nerves, known as the myelin sheath, in the brain and along the spinal cord. This can cause a disruption in the communication between the brain and the rest of the body. ("Multiple Sclerosis Information Page.")…

    • 1062 Words
    • 5 Pages
    Great Essays
  • Improved Essays

    Multiple sclerosis (MS) is a muscular disease that affects the central nervous system (CNS) which consists of the brain and the spinal cord. This disease was discovered by Dr. Jean Martin Charcot. Eventually, improvements in microscopes helped doctors in the search of understanding the disease. In 1916, a Scottish doctor named James Dawson was able to clearly describe the inflammation after viewing the brain cells of a patient with multiple sclerosis through a microscope. Over the years, numerous clinical trials involving potential treatments and diagnostics took place in the 1990’s.…

    • 896 Words
    • 4 Pages
    Improved Essays