Scheme 11: Synthesis of 3h & 3i from 2a-i.
Compounds:
3h : 7-Hydroxy-3-(4-methoxybenzyl)chromanone(Dihydrobonducelin) R1=OH, R2=R3=H,R4=OCH3
3i : 7-Hydroxy-3-(2,4-dimethoxybenzyl)chromanone (2’-Methoxydihydrobonducellin) R1=OH,R3=H,R2=R4=OCH3
Antioxidant activity of above synthesized derivatives were studied, on that basis 3-benzylchromones with phenolic hydroxyl group (2h & 2i) showed highest activity than com-pound with methoxyl group (2e & 2g) because double bond between C2-C3 done major im-pact on activity of compound. The result of inhibition concentration (IC50 in µM) for 2h & 2i were 162 µM and 158 µM respectively.
Antifungal activity of all derivatives were tested and on that basis compound 2i showed high-est activity because presence …show more content…
The synthesized molecules referred as E-and Z-isomers on the basis of NMR Spectroscopic data as reported. Conversion of E-isomer to Z-isomers take place by the process of photoisomerisation, chemical shift and differences between E-and Z-isomers in proton NMR spectral data was useful parameters for ascertaining to stereochemistry. All this synthesized molecules showed antioxidant activity using superoxide (NBT) and DPPH free radical scavenging method. The synthesized derivative compound 7-hydroxy-3-[(3,4,5-trihydrophenyl)methylene]chroman-4-one showed maximum activity over commercially available antioxidant BHA,BHT etc.The derivative compound 7-hydroxy-3-[(N,N-dimethylaminophenyl)methylene]chroman-4-one showed maximum inhibitory activity over the standard nordihydroguiaretic acid when evaluated in vitro for their inhibitory activity against 5-lipoxygenase(5-LOX)
Compounds:
3h : 7-Hydroxy-3-(4-methoxybenzyl)chromanone(Dihydrobonducelin) R1=OH, R2=R3=H,R4=OCH3
3i : 7-Hydroxy-3-(2,4-dimethoxybenzyl)chromanone (2’-Methoxydihydrobonducellin) R1=OH,R3=H,R2=R4=OCH3
Antioxidant activity of above synthesized derivatives were studied, on that basis 3-benzylchromones with phenolic hydroxyl group (2h & 2i) showed highest activity than com-pound with methoxyl group (2e & 2g) because double bond between C2-C3 done major im-pact on activity of compound. The result of inhibition concentration (IC50 in µM) for 2h & 2i were 162 µM and 158 µM respectively.
Antifungal activity of all derivatives were tested and on that basis compound 2i showed high-est activity because presence …show more content…
The synthesized molecules referred as E-and Z-isomers on the basis of NMR Spectroscopic data as reported. Conversion of E-isomer to Z-isomers take place by the process of photoisomerisation, chemical shift and differences between E-and Z-isomers in proton NMR spectral data was useful parameters for ascertaining to stereochemistry. All this synthesized molecules showed antioxidant activity using superoxide (NBT) and DPPH free radical scavenging method. The synthesized derivative compound 7-hydroxy-3-[(3,4,5-trihydrophenyl)methylene]chroman-4-one showed maximum activity over commercially available antioxidant BHA,BHT etc.The derivative compound 7-hydroxy-3-[(N,N-dimethylaminophenyl)methylene]chroman-4-one showed maximum inhibitory activity over the standard nordihydroguiaretic acid when evaluated in vitro for their inhibitory activity against 5-lipoxygenase(5-LOX)